From: Proteomic characterization of serine hydrolase activity and composition in normal urine
Serine hydrolase | Type | Uniprot number | MW (kDa) | Log(e)§ | Potential role(s) |
---|---|---|---|---|---|
Kallikrein-1 (tissue kallikrein) | Protease, S1 | P06870 | 28.889 | -38.8 | 1. Cleaves kininogen to kinins, which act on the B1 & B2 receptor. |
2. Luminal TK activates ENaC to increase Na reabsorption. | |||||
3. Luminal TK increases TRPV5 Ca reabsorption via a B2 receptor-dependent mechanism. | |||||
4. Luminal TK inhibits H+/K+ ATPase to decrease K reasbsorption. | |||||
Plasma kallikrein | Protease, S1 | P03952 | 71.370 | -5.8 | 1. Cleaves kininogen to kinins, which act on the B1 & B2 receptor. |
Prostate specific antigen (kallikrein-3) | Protease, S1 | P07288 | 28.741 | -3.2 | 1. Liquefaction of semen, for sperm to move freely. |
Lysosomal protective protein (cathepsin A) | Protease, S10 | P10619 | 54.466 | -57.1 | 1. Cleaves angiotensin I to angiotensin 1–9, which enhances the kinin effect on the B2 receptor. |
Plasminogen¶ | Protease, S1 | P00747 | 90.569 | -3.5 | 1. Luminal plasmin activates ENaC to increase Na reabsorption. |
2. Luminal plasmin inhibits TRPV5 mediated Ca reabsorption. | |||||
3. Fibrinolysis | |||||
Urokinase-type plasminogen activator | Protease, S1 | P00749 | 45.507 | -38.2 | 1. Cleaves the zymogen plasminogen to plasmin. |
2. Fibrinolysis | |||||
Prothrombin | Protease, S1 | P00734 | 70.037 | -32.4 | 1. Fibrinolysis |
2. Function in urine unknown | |||||
Complement C1r subcomponent-like protein | Protease, S1 | Q9NZP8 | 53.462 | -81.7 | 1. Cleaves pro-C1s, to help activate the classical complement pathway. |
Mannan binding lectin serine protease 2 | Protease, S1 | O00187 | 20.629 | -28.7 | 1. Cleaves C2 and C4, to help activate the lectin complement pathway. |
Myeloblastin (Proteinase 3) | Protease, S1 | P24158 | 27.807 | -5.2 | 1. Neutrophil activation |
2. Cleaves human cathelicidin-18 into antimicrobial peptide LL-37. | |||||
Sialate O-acetylesterase | Carboxyl esterase | Q9HAT2 | 58.315 | -48.6 | 1. Negatively regulates B cell receptor signalling – role in B cell tolerance. |
2. Function in urine unknown | |||||
Bile salt-activated lipase | Type B carboxyl esterase/lipase | P19835 | 79.321 | -128.6 | 1. Lipolysis |
2. Function in urine unknown | |||||
S-formylgluthathione hydrolase | Esterase D | P10768 | 31.462 | -6.6 | 1. Function in urine unknown |