Fig. 3

Characterization of the plasma proteome of CRC patients with FOLFOX chemotherapy. A Scores plot for Partial least square-discriminant analysis (PLS-DA). The scores plot showed separation between the two groups based on their expression. SENS group showed in red and NONE group in blue circles. B Volcano plot representing the difference in plasma expression levels of 115 proteins between the two groups. Red and blue dots indicate proteins with increased and decreased expression levels, respectively. p < 0.01, fold change [SENS/NONE] > 2 (log2FC > 1). C Bar chart showing significant canonical pathways (B–H p-value < 0.05) enriched by Gene Ontology Biological Processes (GOBP). D Dots plot showing the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. E Molecular Complex Detection (MCODE) networks. Each color represents a cluster of protein–protein interaction