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Table 2 Tcorr performance using predefined subsets of b and y ions

From: Critical Evaluation of Product Ion Selection and Spectral Correlation Analysis for Biomarker Screening Using Targeted Peptide Multiple Reaction Monitoring

 

ROC area

Tcorr performed using b and y ions with smallest m/z values above half the precursor mass as transition ions

Size of candidate peptide pool

4 y ions

4 b ions

4 b and 4 y ions

10

0.844

0.807

0.917

100

0.511

0.381

0.835

1,000

0.042

0.008

0.541

Tcorr performed using b and y ions with smallest m/z values below half the precursor mass as transition ions

10

0.848

0.571

0.888

100

0.503

0.147

0.674

1,000

0.039

0.013

0.311

  1. The ROC area data were based on the first (DIMS) spectrum library of 384 peptides