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Table 1 Selected candidate biomarkers

From: A Targeted Proteomics Approach for Biomarker Discovery Using Bilateral Matched Nipple Aspiration Fluids

  

Invasive Ductal Carcinoma (Stage I/II)

DCIS

ADH

 

Score

Protein name

Patient ID

35

36

39

43

50

56

57

61

72

85

94

102

80

58

84

31

48

8186

N+

N

(N+ − N)

Nonmetastatic cells 1, protein

NME1

/

/

/

/

+

/

+

+

+

/

/

+

/

+

/

/

/

/

6

0

6

protein tyrosine kinase 2 beta

PTK2B

/

/

/

+

+

/

/

+

+

/

/

+

/

+

/

/

/

6

1

5

Arrestin beta 1

ARRB1

+

/

/

/

+

/

/

/

+

/

/

+

/

+

+

+

/

6

1

5

Rho interacting protein 3

MRIP

+

/

/

/

+

/

/

/

+

/

/

+

/

+

/

+

6

2

4

GDNF family receptor alpha 1

GFRA1

/

/

/

/

+

/

/

+

/

/

+

/

/

+

/

/

+

5

1

4

Adenomatosis polyposis coli

APC

+

/

+

/

+

/

/

/

/

/

/

+

/

/

+

/

/

5

1

4

Heat shock 60 kDa protein 1 (chaperonin)

HSPD1

/

/

+

+

+

/

/

/

/

/

/

/

+

/

/

/

/

/

4

0

4

Lymphocyte cytosolic protein 2

SLP76

/

/

/

+

/

/

/

+

+

/

/

/

/

/

+

/

/

/

4

0

4

Cathepsin D

CATD

/

/

/

+

/

/

/

+

/

/

/

/

/

+

/

3

3

0

  1. + elevated protein level in affected vs nonaffected breast (defined as >15% elevation reproducible on reciprocal slides), decreased protein level in affected vs nonaffected breast (defined as >15% reduction reproducible on reciprocal slides), / no significant change (defined as changes <15%, or changes not reproducible on reciprocal slides), N+ number of patients showed elevated antigen expression in the affected breast, N number of patients showed decreased antigen expression in the affected breast, * cathepsin D is included in this table for reference to the western blot analysis in Fig. 1, not as a candidate biomarker