Hydrophobic Proteome Analysis of Triple Negative and Hormone-Receptor-Positive-Her2-Negative Breast Cancer by Mass Spectrometer

Table 5 Proteins over-expressed by TNBC (≥2-fold of up-regulation) when compared with ER+PR+Her2− (non-TNBC) cases

Proteins over-expressed in TNBC	Accession no.	Molecular weight (kDA)	Fold of TNBC/non-TNBC	Average detected spectra of TNBC ± SE
Serine (or cysteine) proteinase inhibitor, clade H, member 1	gi\|32454741	46	4.7	11.3 ± 6.4
Filamin A, alpha isoform 2	gi\|160420317	281	4.5	36.1 ± 12.9
Mitochondrial ATP synthase beta subunit	gi\|32189394	57	3.7	31.6 ± 11.1
Heat shock protein 90 kDa beta, member 1	gi\|4507677	92	3.3	30.1 ± 8.9
Tropomyosin 4 isoform 2	gi\|4507651	29	3.2	16.8 ± 6.6
Tropomyosin 3	gi\|58652133	33	3.1	1.1 ± 0.5
ATP synthase, alpha subunit	gi\|4757810	60	2.9	24.8 ± 6.6
Heat shock 70 kDa protein 5	gi\|16507237	72	2.9	54.4 ± 18.2
Three-dimensional structure of a transglutaminase	gi\|1127268 (+4)	83	2.8	6.2 ± 2.0
High-mobility group box 1	gi\|4504425	25	2.7	7.8 ± 2.6
Moesin	gi\|4505257	68	2.7	6.6 ± 2.8
Thymidine phosphorylase	gi\|118138578 (+1)	50	2.5	14.4 ± 5.6
Enolase 1	gi\|4503571	47	2.5	53.5 ± 14.0
Fascin 1	gi\|4507115	55	2.3	4.2 ± 2.3
Fibrinogen, beta chain	gi\|70906435	56	2.3	6.0 ± 3.8
Ribophorin I precursor	gi\|4506675	69	2.3	5.5 ± 1.9
Tryptophanyl-tRNA synthetase isoform a	gi\|47419914	53	2.2	6.0 ± 4.2
Cytoplasmic domain of erythrocyte band-3 protein	gi\|14277739 (+1)	43	2.1	6.1 ± 2.7
Vimentin	gi\|62414289	54	2.1	32.4 ± 9.6
Annexin I	gi\|4502101	39	2.1	25.7 ± 11.5
Vitronectin	gi\|88853069	54	2.1	4.4 ± 1.8
Lamin A/C isoform 1	gi\|27436946	74	2	3.1 ± 2.2
Annexin A2 isoform 2	gi\|4757756	39	2	75.6 ± 20.8
Collagen, type XII, alpha 1 long isoform	gi\|93141047	333	2	2.9 ± 2.9
Vitamin D-binding protein I	gi\|21730554 (+2)	42	2	36.9 ± 6.7
Porin 31HM	gi\|238427 (+1)	31	2	63.7 ± 1.5

ISSN: 1559-0275