Table 6 Selected proteins down-regulated (≤0.5-fold) in triple-negative breast cancer (TNBC) tumor when compared with ER+PR+Her2− (non-TNBC) tumor specimens (keratin data are listed in Table 7)
Proteins down-regulated in TNBC | Accession no. | Molecular weight (kDa) | Fold of TNBC/non-TNBC | Average detected spectra of TNBC ± SE |
|---|---|---|---|---|
Fatty acid synthase | gi|67476453 | 273 | 0.08 | 1.0 ± 0.7 |
Collagen alpha-3(VI) chain | gi|5921193 | 344 | 0.2 | 5.8 ± 1.9 |
Amine oxidase, copper containing 3 | gi|4502119 (+1) | 85 | 0.3 | 1.1 ± 0.5 |
UDP-glucose dehydrogenase | gi|4507813 | 55 | 0.4 | 0.1 ± 0.1 |
Collagen, type XIV, alpha 1 | gi|55743096 | 194 | 0.4 | 13.6 ± 3.7 |
Triosephosphate isomerase 1 isoform 1 | gi|4507645 (+2) | 27 | 0.5 | 6.5 ± 1.9 |
Periostin, osteoblast specific factor isoform 1 | gi|209862907 | 93 | 0.5 | 7.4 ± 2.8 |
Transketolase isoform 1 | gi|4507521 | 68 | 0.5 | 9.2 ± 4.3 |
Heat shock protein beta-1 | gi|4504517 | 23 | 0.5 | 1.0 ± 0.6 |
Lumican precursor | gi|4505047 | 38 | 0.5 | 5.8 ± 2.4 |
Plasma membrane associated protein, S3-12 | gi|122937195 | 134 | 0.5 | 0.5 ± 0.4 |
Osteoglycin | gi|7661704 | 34 | 0.5 | 0.5 ± 0.3 |
Immunoglobulin J chain | gi|400044 | 16 | 0.5 | 0.4 ± 0.2 |
Chain A, the intact and cleaved human antithrombin Iii complex | gi|999513 | 49 | 0.5 | 3.7 ± 2.4 |
CD36 antigen | gi|48375176 | 53 | 0.5 | 0.5 ± 0.5 |
Zinc-alpha-2-glycoprotein | gi|141596 (+1) | 34 | 0.5 | 0.1 ± 0.1 |
Perilipin | gi|8134637 | 60 | 0.5 | 0.1 ± 0.1 |