Table 2 Proteins detected with iTRAQ that are differentially expressed comparing benign and malignant serous ovarian cyst samples

Less expressed in malignant samples

ASTL

Q6HA08

Astacin-like metalloendopeptidase

< 0.001

8.48

ALB

P02768

Albumin

0.001

2.63

C7

P10643

Complement component 7

0.002

1.85

AMY1A

P04745

Amylase, alpha 1A

0.01

6.93

SPARCL1

Q14515

SPARC-like 1 (hevin)

0.01

2.82

PLTP

P55058

Phospholipid transfer protein

0.02

1.80

ABI3BP

Q7Z7G0

Target of Nesh-SH3 (TARSH)

0.02

1.80

CTSD

P07339

Cathepsin D

0.02

2.95

CHAF1A

Q13111

Chromatin assembly factor 1, subunit A

0.03

1.93

COL6A3

P12111

Collagen, type VI, alpha 3

0.03

2.22

CRISP3

P54108

Cysteine-rich secretory protein 3

0.04

2.59

KIAA0196

Q12768

Strumpellin (STRUM)

0.04

1.92

MSLN

Q13421

Mesothelin

0.04

3.02

OVGP1

Q12889

oviductal glycoprotein 1

0.05

6.53

More expressed in malignant samples

APOA1

P02647

Apolipoprotein A-I

0.002

2.62

APOB

P04114

Apolipoprotein B

0.004

2.43

HSPA5 /GRP78

P11021

heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa)

0.005

3.34

APOA4

P06727

Apolipoprotein A-IV

0.02

3.31

IDHC

O75874

Isocitrate dehydrogenase 1 (NADP+)

0.02

4.27

ALDOA

P04075

Aldolase A, fructose-bisphosphate

0.02

2.70

TPI1

P60174

Triosephosphate isomerase 1

0.02

2.18

GAPDH

P04406

Glyceraldehyde-3-phosphate dehydrogenase

0.03

2.76

C4BPA

P04003

Complement component 4 binding protein, alpha

0.03

1.80

CLTC

Q00610

Clathrin, heavy chain

0.03

2.69

APOC1

P02654

Apolipoprotein C-I

0.04

1.87

S100A8

P05109

S100 calcium binding protein A8

0.04

4.35

SYT13

Q7L8C5

Synaptotagmin XIII

0.04

1.97

YWHAZ

P63104

Tyrosine 3-monooxygenase/tryptophan 5-mono-oxygenase activation protein, zeta polypeptide

0.04

3.79

APCS

P02743

Amyloid P-component , serum

0.04

2.12

SAA4

P35542

Serum amyloid A-4, constitutive

0.04

1.95

PRDX2

P32119

Peroxiredoxin 2

0.04

4.03

S100A9

P06702

S100 calcium binding protein A9

0.05

3.43