| Study I | Study II | Study III | Combined HPS dataset | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 | CV (%) | CV (%) | CV (%) | Generalized CV (%) | CV (%) | Generalized CV (%) | ||||||
Protein | InteQuan | SISQuan | InteQuan | SISQuan | InteQuan | SISQuan | InteQuan | SISQuan | InteQuan | SISQuan | InteQuan | SISQuan |
KIT | 8.8 | 9.6 | 4.3 | 10.5 | 7.8 | 35.0 | 7.7 | 6.5 | 10.5 | 31.7 | 10.6 | 12.8 |
FRIL | 16.8 | 25.2 | 5.3 | 11.8 | 7.3 | 33.6 | 7.3 | 12.0 | 15.9 | 25.4 | 16.7 | 18.8 |
COIA1 | 12.6 | 17.8 | 9.0 | 9.7 | 10.4 | 38.5 | 10.2 | 14.1 | 16.1 | 31.1 | 16.6 | 17.5 |
PRDX1 | 10.7 | 15.4 | 4.9 | 11.8 | 9.6 | 32.2 | 9.4 | 14.6 | 31.9 | 15.8 | 31.8 | 15.5 |
TENX | 11.1 | 13.6 | 8.8 | 12.7 | 10.7 | 26.6 | 10.8 | 11.1 | 10.7 | 32.3 | 10.6 | 15.2 |
ENPL | 13.1 | 18.9 | 11.2 | 8.6 | 11.3 | 34.9 | 11.3 | 13.6 | 11.7 | 32.9 | 11.8 | 12.6 |
GRP78 | 6.8 | 11.4 | 19.3 | 24.2 | 11.5 | 33.7 | 11.2 | 12.9 | 13.9 | 28.5 | 13.6 | 18.4 |
BGH3 | 5.0 | 12.3 | 5.7 | 9.9 | 12.4 | 42.3 | 12.4 | 13.8 | 9.8 | 33.7 | 9.6 | 14.9 |
ALDOA | 6.6 | 13.6 | 9.1 | 17.5 | 15.1 | 35.4 | 14.9 | 19.9 | 11.0 | 35.4 | 11.2 | 14.9 |
GGH | 6.9 | 7.1 | 9.0 | 13.7 | 13.9 | 38.9 | 13.7 | 16.5 | 11.0 | 31.7 | 10.5 | 16.6 |
CD14 | 4.1 | 8.0 | 4.6 | 12.0 | 4.6 | 35.3 | 4.7 | 6.8 | 7.9 | 30.5 | 7.8 | 11.9 |
LG3BP | 8.8 | 13.0 | 5.9 | 10.0 | 5.6 | 31.1 | 5.6 | 7.5 | 8.6 | 30.5 | 8.5 | 13.9 |
TSP1 | 11.6 | 18.3 | 12.9 | 17.0 | 21.5 | 45.7 | 20.9 | 21.9 | 20.3 | 41.1 | 22.9 | 25.3 |
IBP3 | 5.7 | 11.6 | 6.3 | 13.5 | 13.5 | 41.5 | 14.0 | 15.5 | 19.8 | 26.7 | 20.5 | 21.6 |
TETN | 9.9 | 17.8 | 9.9 | 12.4 | 25.5 | 52.3 | 26.9 | 29.7 | 33.1 | 47.6 | 33.3 | 37.7 |
ISLR | 10.0 | 9.1 | 4.7 | 10.0 | 4.2 | 31.3 | 4.2 | 5.0 | 12.2 | 33.8 | 12.1 | 9.6 |
Median CV (%) | 9.3 | 13.3 | 7.6 | 11.9 | 11.0 | 35.1 | 11.0 | 13.7 | 11.9 | 31.7 | 11.9 | 15.3 |
Median of CV reductiona (%) | 4.9 | Â | 4.8 | Â | 25.9 | Â | 2.0 | Â | 21.0 | Â | 3.0 | Â |
Total proteins with lower CV | 15 | 1 | 15 | 1 | 16 | 0 | 15 | 1 | 15 | 1 | 14 | 2 |
P value (paired sign test) | 5.2 × 10-4 | 5.2 × 10-4 | 3.1 × 10-5 | 5.2 × 10-4 | 5.2 × 10-4 | 4.2 × 10-3 | ||||||
Comments | CV of 10 HPS aliquots | Median CV of 15 clinical samples | Median CV of 6 samples | CV of 29 HPS aliquots |