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Table 1 Association of enzyme metabolic rates to genotypes

From: Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance

Classical metabolism status

Activity score 1

Genotypes

Poor metabolizer (PM)

0.0

Homozygous null gene

 

0.5

Heterozygous null and reduced metabolism

Intermediate metabolizer (IM)

1.0

Homozygous reduced metabolism

  

Heterozygous null and wildtype

 

1.5

Heterozygous reduced metabolism and wildtype

Extensive metabolizer (EM)

2.0

Homozygous wildtype

  

Heterozygous null and ultra metabolism

  

Heterozygous reduced and ultra metabolism

Ultra-rapid metabolizer (UM)

> 2.0

Heterozygous wildtype and ultra metabolism

  

Homozyogous ultra metabolism

  1. 1For each allele, a score of 0 is given for null genes, 0.5 for intermediate, and1.0 for extensive metabolizers. Alleles carrying gene duplications receive double the value compared to the assigned activity score with a single gene copy. The sum of both alleles is given.
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Clinical Proteomics

ISSN: 1559-0275