Fig. 3

A: Protein-protein interactions of the differentially expressed proteins. The red bubbles represent the immune-related proteins ORM1, vWF, SPARC and PPBP; these four proteins interact with each other. The blue bubbles represent other differentially expressed proteins. B: Mass spectrometry-based targeted proteomics was conducted to quantify the four immune-related proteins. The levels of ORM1 and vWF were significantly higher in ITP samples than in control samples, while the levels of SPARC and PPBP were lower in ITP samples than in control samples. Two-tailed Student’s t-tests were used to compare the two groups. *P < 0.05, **P < 0.01, ***P < 0.001