Fig. 1

Analysis of biomarkers in sera from primary and recurrent ovarian cancer patients as well as healthy controls. A–I, Log10 transformed expression of B7-H3, IL-6, PLA2G7, Tie-1, GDF-15, IL-6 R alpha, SDC1, VCAM-1, and CA-125 in primary (Pri) and recurrent (Rec) ovarian cancer (OvCa) as well as healthy controls are demonstrated in scatterplots. Biomarkers demonstrating significant differences between Pri OvCa and Rec OvCa or between OvCa (or Pri OvCa or Rec OvCa) and healthy controls are shown with asterisks (Kruskal–Wallis test followed by Dunn’s multiple comparisons test). Bars indicate median value. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 (two-tailed)