Identification of SARS-CoV-2 biomarkers in saliva by transcriptomic and proteomics analysis

Table 6 List of replicase polyproteins 1a and 1ab tryptic peptides identified in saliva samples collected from COVID-19 positive individuals grouped by the polyprotein fragment to which they belong and their functions

Protein name	Peptide sequence	Polyprotein fragment name	Polyprotein fragment function
R1A/R1AB	LTDNVYIK	Nsp-3	Papain-like protease
	RVLNVVCK
	TFYVLPNDDTLR
	TTEVVGDIILKPANNSLK
	IALKGGK	Nsp-4	NS
	IVNNWLKQLIK
	IVQLSEISMDNSPNLAWPLIVTALR
	VIGHSMQNCVLKLK	Nsp-5	3C-like proteinase
	KSLNVAK	Nsp-8	NS
	SHnIALIWnVKDFmSLSEQLR	Nsp-8	NS
	WARFPK	Nsp-9	NS
R1AB	LKLFDR	Nsp-12	RNA-directed RNA polymerase
	EFLTRNPAWR	Nsp-13	Helicase
	VSAKPPPGDQFK	Nsp-14	Proofreading exonuclease
	NLQEFKPR	Nsp-15	Uridylate-specific endoribonuclease
	QASLNGVTLIGEAVK	Nsp-15	Uridylate-specific endoribonuclease

R1A replicase polyprotein 1a (accession number: P0DTC1), R1AB replicase polyprotein 1ab (accession number: P0DTD1), Nsp Non-structural protein, NS Non-specific

ISSN: 1559-0275