Fig. 2
From: Cerebrospinal fluid camk2a levels at baseline predict long-term progression in multiple sclerosis
Candidate biomarkers in Ottawa Biobank CSF samples from non-inflammatory controls (n = 19), and MS patients (n = 34) measured using our PRM assay6. Relative protein quantification of 6 significant brain-enriched proteins in CSF. Ratio of endogenous protein to isotopically labelled peptides (standard) was lower for MS patients compared to control group (Mann-Whitney U, p-value; CAMK2A p = 0.0476, CNTNAP4 p = 0.0298, IGLON5 p = 0.0434, RTN4RL2 p = 0.0396, SEZ6L p = 0.0396, TMEM132D p = 0.0197). Lines and boxes represent median and interquartile range while bars represent range