Fig. 4
From: Cerebrospinal fluid camk2a levels at baseline predict long-term progression in multiple sclerosis
Baseline CAMK2A levels and disease progression. (A) Average rate (median, interquartile range and total range) of EDSS progression (change in EDSS score/year; over time in subgroups of MS patients based on CSF CAMK2A tertiles at baseline (Kruskal-Wallis p = 0.0143). (B) Trajectory of EDSS over long-term follow-up time in subgroups of MS patients based on CSF CAMK2A tertiles at baseline (full GEE results in Table 3). (C) Comparison of baseline CAMK2A levels and rate of EDDS change per year. Shading of squares represents baseline EDSS score (Unshaded, baseline EDSS less than 4; Shaded, baseline EDSS greater than or equal to 4). Coloring of squares represents final EDSS score by the end of follow-up time (Red, final EDSS less than 4; Blue, final EDSS greater than or equal to 4). Kaplan-Meier survival curves to compare: (D) hazard of progression to EDSS ≥ 4 (LR chi sq = 8, 2df, p = 0.02) (E) hazard of developing progressive MS (LR chi-sq = 13.1, 2df, p = 0.001) after follow-up in subgroups of MS patients based on CSF CAMK2A tertiles at baseline