Table 1 MR associations

ANGPTL7

Angiopoietin-related protein 7: formation and organization of extracellular matrix. Negative regulator of angiogenesis in cornea. Plays role in maintaining corneal avascularity and transparency

↓Age at menopause, ↓BMI, ↓HDL, ↑Type II diabetes, ↑WHR

SEMA3F

Semaphorin-3F: involved in cell signaling

↓Alcohol use disorder, ↓BMI, ↓Problematic alcohol use, ↑WHR, ↑Inflammatory bowel disease, ↑Type II diabetes

ARG1

Arginase-1: enzyme in urea cycle converting L-arginine to urea and L-ornithine

↓BMI, ↑GFR, ↓Type II Diabetes

NTPROBNP

Natriuretic peptides B: hormone plays a role in mediating extracellular fluid volume and cardio-renal homeostasis

↑BMI, ↑VTE

NECTIN2

Nectin-2: modulator of T-cell signaling

↓CAD, ↓LDL, ↓Total cholesterol, ↑HDL

CD79B

B-cell antigen receptor complex-associated protein beta chain: involved in signal cascade activated by B-cell antigen receptor complex

↑HDL, ↑Rheumatoid arthritis, ↑WHR

RTN4R

Reticulon-4 receptor: receptor for several ligands

↓Pulse pressure, ↓Systolic blood pressure

DDC

Aromatic-l-amino-acid decarboxylase: enzyme that catalyzes the conversion of l-3,4-dihydroxyphenylalanine (DOPA) to dopamine, l-5-hydroxytryptophan to serotonin and l-tryptophan to tryptamine

↓Type I diabetes

TYRO3

Tyrosine-protein kinase receptor: receptor tyrosine kinase that transduces signal from extracellular matrix to cytoplasm, binds several different ligands

↑Type II diabetes

FAM3C

Family with sequence similarity 3 member C: possible involvement in retinal laminar formation. Promotes epithelial to mesenchymal transition

↓WHR

TSHB

Thyrotropin subunit beta: subunit of hormone mediating thyroid function

↓Atrial fibrillation

ENTPD5

Ectonucleoside triphosphate diphosphohydrolase 5: a Uridine diphosphatase involved in protein N-glycosylation and ATP regulation

↓Type 1 diabetes, ↑Inflammatory bowel disease

CD1C

T-cell surface glycoprotein CD1c: protein presents to antigens to T-cell receptors on natural killer T-cells

↑Inflammatory bowel disease

TYMP

Thymidine phosphorylase: catalyzes the reversible phosphorolysis of thymidine

↑Inflammatory bowel disease, ↑Total cholesterol, ↓Prostate cancer

ITGB7

Integrin beta-7: adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue

↓Total cholesterol

NOMO1

Nodal modulator 1: involved in membrane protein transport into the endoplasmic reticulum

↑LDL, ↑Total cholesterol

ADGRE2

Adhesion G protein-coupled receptor E2: cell surface receptor, promotes cell attachment, granulocyte chemotaxis, degranulation, and adhesion

↓Total cholesterol

COMT

Catechol O-methyltransferase: enzyme that catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones

↓Type II diabetes