Table 1 Examples of LC-MS/MS- based FDA approved tests in clinical laboratory
From: Mass spectrometry-based proteomics as an emerging tool in clinical laboratories
Technology | Identification | Sample | Diseases | Year | Ref. |
|---|---|---|---|---|---|
HPLC-MS/MS (MRM) | Wild-type (wt) amyloid β (Aβ) | Cerebrospinal fluid / FFPE | Alzheimer’s disease (AD) | 2020 | [102] |
VITEK-MS (VITEK 2Â ) | Microbes and AMR profile | Microbial sample | Infectious diseases | 2013 | [104] |
Bruker MALDI Biotyper CA System | Gram-negative and gram-positive bacteria and yeast | Bacterial sample | Infectious diseases | 2013 | |
OVA1, in vitro diagnostic multivariate index assay (SELDI-TOF-MS) | CA 125, TTR, ApoA1, β-2 microglobulin, TF | Serum | Ovarian cancer | 2009 | [107] |