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  1. Research

    Plasma degradome affected by variable storage of human blood

    The successful application of—omics technologies in the discovery of novel biomarkers and targets of therapeutic interventions is facilitated by large collections of well curated clinical samples stored in bio...

    Maria Kaisar, Leon F. A. van Dullemen, Marie-Laëtitia Thézénas, M. Zeeshan Akhtar, Honglei Huang, Sandrine Rendel, Philip D. Charles, Roman Fischer, Rutger J. Ploeg and Benedikt M. Kessler

    Clinical Proteomics 2016 13:26

    Published on: 26 September 2016

  2. Review

    Precision medicine: from pharmacogenomics to pharmacoproteomics

    Disease progression and drug response may vary significantly from patient to patient. Fortunately, the rapid development of high-throughput ‘omics’ technologies has allowed for the identification of potential ...

    Allison B. Chambliss and Daniel W. Chan

    Clinical Proteomics 2016 13:25

    Published on: 26 September 2016

  3. Research

    Increased sialylation of site specific O-glycoforms of hemopexin in liver disease

    Non-invasive monitoring of liver disease remains an important health issue. Liver secreted glycoproteins reflect pathophysiological states of the organ and represent a rational target for serologic monitoring....

    Miloslav Sanda, Julius Benicky, Jing Wu, Yiwen Wang, Kepher Makambi, Jaeil Ahn, Coleman I. Smith, Peng Zhao, Lihua Zhang and Radoslav Goldman

    Clinical Proteomics 2016 13:24

    Published on: 21 September 2016

  4. Research

    Development of a liquid chromatography high resolution mass spectrometry method for the quantitation of viral envelope glycoprotein in Ebola virus-like particle vaccine preparations

    Ebola virus like particles (EBOV VLPs, eVLPs), are produced by expressing the viral transmembrane glycoprotein (GP) and structural matrix protein VP40 in mammalian cells. When expressed, these proteins self-a...

    Lisa H. Cazares, Michael D. Ward, Ernst E. Brueggemann, Tara Kenny, Paul Demond, Christopher R. Mahone, Karen A. O. Martins, Jonathan E. Nuss, Trevor Glaros and Sina Bavari

    Clinical Proteomics 2016 13:18

    Published on: 5 September 2016

  5. Research

    A proteomic evaluation of urinary changes associated with cardiopulmonary bypass

    The urinary proteome of patients undergoing cardiopulmonary bypass (CPB) may provide important insights into systemic and renal changes associated with the procedure. Such information may ultimately provide a ...

    Ravi C. Dwivedi, Mario Navarrete, Nora Choi, Victor Spicer, Claudio Rigatto, Rakesh C. Arora, Oleg Krokhin, Julie Ho and John A. Wilkins

    Clinical Proteomics 2016 13:17

    Published on: 15 August 2016

  6. Research

    Quantification of angiotensin II-regulated proteins in urine of patients with polycystic and other chronic kidney diseases by selected reaction monitoring

    Angiotensin-II (Ang II) mediates progression of autosomal-dominant polycystic kidney disease (ADPKD) and other chronic kidney diseases (CKD). However, markers of kidney Ang II activity are lacking. We previous...

    Ana Konvalinka, Ihor Batruch, Tomas Tokar, Apostolos Dimitromanolakis, Shelby Reid, Xuewen Song, York Pei, Andrei P. Drabovich, Eleftherios P. Diamandis, Igor Jurisica and James W. Scholey

    Clinical Proteomics 2016 13:16

    Published on: 5 August 2016

  7. Research

    Identification of potential protein biomarkers for early detection of pregnancy in cow urine using 2D DIGE and label free quantitation

    An early, reliable and noninvasive method of early pregnancy diagnosis is prerequisite for efficient reproductive management in dairy industry. The early detection of pregnancy also help in to reduce the calvi...

    Preeti Rawat, Shveta Bathla, Rubina Baithalu, Munna Lal Yadav, Sudarshan Kumar, Syed Azamal Ali, Anurag Tiwari, Masoud Lotfan, Jasmine Naru, Manoj Jena, Pradip Behere, Ashok K. Balhara, Rajesh Vashisth, Inderjeet Singh, Ajay Dang, Jai K. Kaushik…

    Clinical Proteomics 2016 13:15

    Published on: 15 July 2016

  8. Research

    Quantitative proteomic analysis of histone modifications in decitabine sensitive and resistant leukemia cell lines

    The refractory nature of many cancers remains the main health challenge over the past century. The epigenetic drug, decitabine (DAC), represents one of the most promising therapeutic agents in cancers particul...

    Chunchao Zhang, Jinfeng Suo, Hiroyuki Katayama, Yue Wei, Guillermo Garcia-Manero and Samir Hanash

    Clinical Proteomics 2016 13:14

    Published on: 5 July 2016

  9. Research

    Phosphotyrosine profiling of curcumin-induced signaling

    Curcumin, derived from the rhizome Curcuma longa, is a natural anti-cancer agent and has been shown to inhibit proliferation and survival of tumor cells. Although the anti-cancer effects of curcumin are well esta...

    Gajanan Sathe, Sneha M. Pinto, Nazia Syed, Vishalakshi Nanjappa, Hitendra S. Solanki, Santosh Renuse, Sandip Chavan, Aafaque Ahmad Khan, Arun H. Patil, Raja Sekhar Nirujogi, Bipin Nair, Premendu Prakash Mathur, T. S. Keshava Prasad, Harsha Gowda and Aditi Chatterjee

    Clinical Proteomics 2016 13:13

    Published on: 15 June 2016

  10. Research

    Synovial fluid proteome in rheumatoid arthritis

    Rheumatoid arthritis (RA) is a chronic autoinflammatory disorder that affects small joints. Despite intense efforts, there are currently no definitive markers for early diagnosis of RA and for monitoring the p...

    Mitali Bhattacharjee, Lavanya Balakrishnan, Santosh Renuse, Jayshree Advani, Renu Goel, Gajanan Sathe, T. S. Keshava Prasad, Bipin Nair, Ramesh Jois, Subramanian Shankar and Akhilesh Pandey

    Clinical Proteomics 2016 13:12

    Published on: 5 June 2016

  11. Research

    Identification of brain-enriched proteins in the cerebrospinal fluid proteome by LC-MS/MS profiling and mining of the Human Protein Atlas

    Cerebrospinal fluid (CSF) is a proximal fluid which communicates closely with brain tissue, contains numerous brain-derived proteins and thus represents a promising fluid for discovery of biomarkers of central...

    Ilijana Begcevic, Davor Brinc, Andrei P. Drabovich, Ihor Batruch and Eleftherios P. Diamandis

    Clinical Proteomics 2016 13:11

    Published on: 15 May 2016

  12. Review

    Clinical proteomics of enervated neurons

    The dynamic field of neurosciences entails ever increasing search for molecular mechanisms of disease states, especially in the domain of neurodegenerative disorders. The previous century heralded the techniqu...

    Mohor Biplab Sengupta, Arunabha Chakrabarti, Suparna Saha and Debashis Mukhopadhyay

    Clinical Proteomics 2016 13:10

    Published on: 5 May 2016

  13. Review

    Clinical utility of serum biomarkers in Duchenne muscular dystrophy

    Assessments of disease progression and response to therapies in Duchenne muscular dystrophy (DMD) patients remain challenging. Current DMD patient assessments include complex physical tests and invasive proce...

    Yetrib Hathout, Haeri Seol, Meng Hsuan J. Han, Aiping Zhang, Kristy J. Brown and Eric P. Hoffman

    Clinical Proteomics 2016 13:9

    Published on: 5 April 2016

  14. Research

    Targeted quantification of N-1-(carboxymethyl) valine and N-1-(carboxyethyl) valine peptides of β-hemoglobin for better diagnostics in diabetes

    N-1-(Deoxyfructosyl) valine (DFV) β-hemoglobin (β-Hb), commonly referred as HbA1c, is widely used diagnostic marker in diabetes, believed to provide glycemic status of preceding 90–120...

    Mashanipalya G. Jagadeeshaprasad, Kedar B. Batkulwar, Nishita N. Meshram, Shalbha Tiwari, Arvind M. Korwar, Ambika G. Unnikrishnan and Mahesh J. Kulkarni

    Clinical Proteomics 2016 13:7

    Published on: 29 March 2016

  15. Research

    Targeting LAMP2 in human cerebrospinal fluid with a combination of immunopurification and high resolution parallel reaction monitoring mass spectrometry

    Alzheimer’s disease is the most common form of dementia. An increasing body of evidence suggests that endo-lysosomal dysfunction is a pathogenic mechanism of Alzheimer’s disease. Thus there is a potential for...

    Simon Sjödin, Annika Öhrfelt, Gunnar Brinkmalm, Henrik Zetterberg, Kaj Blennow and Ann Brinkmalm

    Clinical Proteomics 2016 13:4

    Published on: 25 February 2016

  16. Research

    ENOX2-based early detection (ONCOblot) of asbestos-induced malignant mesothelioma 4–10 years in advance of clinical symptoms

    Malignant mesothelioma is an aggressive, almost uniformly fatal tumor, caused primarily by exposure to asbestos. In this study, serum presence of mesothelioma-specific protein transcript variants of ecto-nicot...

    D. James Morré, Brandon Hostetler, David J. Taggart, Dorothy M. Morré, A. W. Musk, Bruce W. S. Robinson and Jenette Creaney

    Clinical Proteomics 2016 13:2

    Published on: 22 January 2016

    The Erratum to this article has been published in Clinical Proteomics 2016 13:3

  17. Review

    Advances in mass spectrometry-based clinical biomarker discovery

    The greatest unmet needs in biomarker discovery are those discoveries that lead to the development of clinical diagnostic tests. These clinical diagnostic tests can provide early intervention when a patient wo...

    Christopher A. Crutchfield, Stefani N. Thomas, Lori J. Sokoll and Daniel W. Chan

    Clinical Proteomics 2016 13:1

    Published on: 7 January 2016

  18. Research

    Mass spectrometry-based analyses showing the effects of secretor and blood group status on salivary N-glycosylation

    The carbohydrate portions of salivary glycoproteins play important roles, including mediating bacterial and leukocyte adhesion. Salivary glycosylation is complex. Many of its glycoproteins present ABO and Lewi...

    Matthew E. Albertolle, Maria E. Hassis, Connie Jen Ng, Severino Cuison, Katherine Williams, Akraporn Prakobphol, Andrew B. Dykstra, Steven C. Hall, Richard K. Niles, H. Ewa Witkowska and Susan J. Fisher

    Clinical Proteomics 2015 12:29

    Published on: 30 December 2015

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