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  1. Research

    OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages

    Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages remains challenging and is imp...

    Florence Quesada-Calvo, Charlotte Massot, Virginie Bertrand, Rémi Longuespée, Noëlla Blétard, Joan Somja, Gabriel Mazzucchelli, Nicolas Smargiasso, Dominique Baiwir, Marie-Claire De Pauw-Gillet, Philippe Delvenne, Michel Malaise, Carla Coimbra Marques, Marc Polus, Edwin De Pauw, Marie-Alice Meuwis…

    Clinical Proteomics 2017 14:9

    Published on: 24 March 2017

  2. Research

    Cervical mucus proteome in endometriosis

    Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. It affects 7–10% of women of reproductive ...

    Giuseppe Grande, Federica Vincenzoni, Domenico Milardi, Giuseppina Pompa, Domenico Ricciardi, Erika Fruscella, Francesca Mancini, Alfredo Pontecorvi, Massimo Castagnola and Riccardo Marana

    Clinical Proteomics 2017 14:7

    Published on: 2 February 2017

  3. Research

    Serum proteomic-based analysis identifying autoantibodies against PRDX2 and PRDX3 as potential diagnostic biomarkers in nasopharyngeal carcinoma

    Nasopharyngeal carcinoma (NPC) is a major head and neck cancer with high occurrence in Southeast Asia and southern China. We aimed to identify autoantibodies that may contribute to early detection of NPC.

    Lie-Hao Lin, Yi-Wei Xu, Li-Sheng Huang, Chao-Qun Hong, Tian-Tian Zhai, Lian-Di Liao, Wen-Jie Lin, Li-Yan Xu, Kai Zhang, En-Min Li and Yu-Hui Peng

    Clinical Proteomics 2017 14:6

    Published on: 1 February 2017

  4. Research

    A new enzyme-linked immunosorbent assay (ELISA) for human free and bound kallikrein 9

    Kallikrein 9 (KLK9) is a member of the human kallikrein-related peptidases family, whose physiological role and implications in disease processes remain unclear. The active form of the enzyme is predicted to h...

    Panagiota Filippou, Dimitrios Korbakis, Sofia Farkona, Antoninus Soosaipillai, Theano Karakosta and Eleftherios P. Diamandis

    Clinical Proteomics 2017 14:4

    Published on: 17 January 2017

  5. Research

    Simultaneous analyses of N-linked and O-linked glycans of ovarian cancer cells using solid-phase chemoenzymatic method

    Glycans play critical roles in a number of biological activities. Two common types of glycans, N-linked and O-linked, have been extensively analyzed in the last decades. N-glycans are typically released from g...

    Shuang Yang, Naseruddin Höti, Weiming Yang, Yang Liu, Lijun Chen, Shuwei Li and Hui Zhang

    Clinical Proteomics 2017 14:3

    Published on: 13 January 2017

  6. Research

    Redox proteomic identification of carbonylated proteins in autism plasma: insight into oxidative stress and its related biomarkers in autism

    Autism is a severe childhood neurological disorder with poorly understood etiology and pathology. Currently, there is no authentic laboratory test to confirm the diagnosis of autism. Oxidative damage may play ...

    Chengyun Feng, Youjiao Chen, Jintao Pan, Aochu Yang, Li Niu, Jie Min, Xianling Meng, Liping Liao, Kaoyuan Zhang and Liming Shen

    Clinical Proteomics 2017 14:2

    Published on: 9 January 2017

  7. Research

    Development of a microarray-based method for allergen-specific IgE and IgG4 detection

    sIgE and sIgG4 detection is necessary for more accurate and effective type I hypersensitivity diagnostics and the estimation of disease development. Typically, the analyses of these antibodies are performed se...

    Guzel Feyzkhanova, Sergei Voloshin, Olga Smoldovskaya, Alla Arefieva, Marina Filippova, Viktor Barsky, Ludmila Pavlushkina, Veronika Butvilovskaya, Alexei Tikhonov, Yuri Reznikov and Alla Rubina

    Clinical Proteomics 2017 14:1

    Published on: 9 January 2017

  8. Research

    Proteome analysis of excretory-secretory proteins of Entamoeba histolytica HM1:IMSS via LC–ESI–MS/MS and LC–MALDI–TOF/TOF

    Excretory-secretory (ES) proteins of E. histolytica are thought to play important roles in the host invasion, metabolism, and defence. Elucidation of the types and functions of E. histolytica ES proteins can furt...

    Jorim Anak Ujang, Soon Hong Kwan, Mohd Nazri Ismail, Boon Huat Lim, Rahmah Noordin and Nurulhasanah Othman

    Clinical Proteomics 2016 13:33

    Published on: 22 November 2016

  9. Research

    Integrated glycomic analysis of ovarian cancer side population cells

    Ovarian cancer is the most lethal gynecological malignancy due to its frequent recurrence and drug resistance even after successful initial treatment. Accumulating scientific evidence indicates that subpopulat...

    Ran Zhao, Xiaoxia Liu, Yisheng Wang, Xiaoxiang Jie, Ruihuan Qin, Wenjun Qin, Mengyu Zhang, Haiyan Tai, Caiting Yang, Lili Li, Peike Peng, Miaomiao Shao, Xingwang Zhang, Hao Wu, Yuanyuan Ruan, Congjian Xu…

    Clinical Proteomics 2016 13:32

    Published on: 10 November 2016

  10. Review

    Proteomics in India: the clinical aspect

    Proteomics has emerged as a highly promising bioanalytical technique in various aspects of applied biological research. In Indian academia, proteomics research has grown remarkably over the last decade. It is ...

    Somaditya Mukherjee and Arun Bandyopadhyay

    Clinical Proteomics 2016 13:21

    Published on: 5 November 2016

  11. Research

    Implementation and evaluation of amyloidosis subtyping by laser-capture microdissection and tandem mass spectrometry

    Correct identification of the amyloidosis-causing protein is crucial for clinical management. Recently the Mayo Clinic reported laser-capture microdissection (LCM) with liquid chromatography-coupled tandem mas...

    Peter Mollee, Samuel Boros, Dorothy Loo, Jayde E. Ruelcke, Vanessa A. Lakis, Kim-Anh Lê Cao, Patricia Renaut and Michelle M. Hill

    Clinical Proteomics 2016 13:30

    Published on: 27 October 2016

  12. Research

    Proteomic profiling of lung adenocarcinoma indicates heightened DNA repair, antioxidant mechanisms and identifies LASP1 as a potential negative predictor of survival

    Lung cancer is the leading cause of cancer mortality in the United States. Non-small cell lung cancer accounts for 85% of all lung cancers for which adenocarcinoma is the most common histological type. Managem...

    Johannes F. Fahrmann, Dmitry Grapov, Brett S. Phinney, Carol Stroble, Brian C. DeFelice, William Rom, David R. Gandara, Yanhong Zhang, Oliver Fiehn, Harvey Pass and Suzanne Miyamoto

    Clinical Proteomics 2016 13:31

    Published on: 27 October 2016

  13. Research

    Proteomic profiling of retinoblastoma by high resolution mass spectrometry

    Retinoblastoma is an ocular neoplastic cancer caused primarily due to the mutation/deletion of RB1 gene. Due to the rarity of the disease very limited information is available on molecular changes in primary r...

    Ravikanth Danda, Kalaivani Ganapathy, Gajanan Sathe, Anil K. Madugundu, Sharavan Ramachandran, Uma Maheswari Krishnan, Vikas Khetan, Pukhraj Rishi, T. S. Keshava Prasad, Akhilesh Pandey, Subramanian Krishnakumar, Harsha Gowda and Sailaja V. Elchuri

    Clinical Proteomics 2016 13:29

    Published on: 26 October 2016

  14. Research

    Antibody-based proteomics to identify an apoptosis signature for early recurrence of hepatocellular carcinoma

    Early recurrence after surgical resection is a hallmark of poor prognosis in hepatocellular carcinoma (HCC). To determine the proteomic background of early recurrence of HCC, we focused on apoptosis-related pr...

    Noriaki Morofuji, Hidenori Ojima, Nobuyoshi Hiraoka, Takuji Okusaka, Minoru Esaki, Satoshi Nara, Kazuaki Shimada, Yoshiro Kishi and Tadashi Kondo

    Clinical Proteomics 2016 13:28

    Published on: 24 October 2016

  15. Research

    Fibrinogen alpha C chain 5.9 kDa fragment (FIC5.9), a biomarker for various pathological conditions, is produced in post-blood collection by fibrinolysis and coagulation factors

    Fibrinogen alpha C chain 5.9 kDa fragment (FIC5.9) is a new serum biomarker for chronic hepatitis that was discovered by proteomics analysis. Previous studies have shown that FIC5.9 is derived from the C-termi...

    Wataru Kikuchi, Motoi Nishimura, Takahisa Kuga, Sachio Tsuchida, Tatsuya Saito, Mamoru Satoh, Kenta Noda, Yoshio Kodera, Takeshi Tomonaga and Fumio Nomura

    Clinical Proteomics 2016 13:27

    Published on: 7 October 2016

  16. Research

    Plasma degradome affected by variable storage of human blood

    The successful application of—omics technologies in the discovery of novel biomarkers and targets of therapeutic interventions is facilitated by large collections of well curated clinical samples stored in bio...

    Maria Kaisar, Leon F. A. van Dullemen, Marie-Laëtitia Thézénas, M. Zeeshan Akhtar, Honglei Huang, Sandrine Rendel, Philip D. Charles, Roman Fischer, Rutger J. Ploeg and Benedikt M. Kessler

    Clinical Proteomics 2016 13:26

    Published on: 26 September 2016

  17. Review

    Precision medicine: from pharmacogenomics to pharmacoproteomics

    Disease progression and drug response may vary significantly from patient to patient. Fortunately, the rapid development of high-throughput ‘omics’ technologies has allowed for the identification of potential ...

    Allison B. Chambliss and Daniel W. Chan

    Clinical Proteomics 2016 13:25

    Published on: 26 September 2016

  18. Research

    Increased sialylation of site specific O-glycoforms of hemopexin in liver disease

    Non-invasive monitoring of liver disease remains an important health issue. Liver secreted glycoproteins reflect pathophysiological states of the organ and represent a rational target for serologic monitoring....

    Miloslav Sanda, Julius Benicky, Jing Wu, Yiwen Wang, Kepher Makambi, Jaeil Ahn, Coleman I. Smith, Peng Zhao, Lihua Zhang and Radoslav Goldman

    Clinical Proteomics 2016 13:24

    Published on: 21 September 2016

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