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Fig. 4 | Clinical Proteomics

Fig. 4

From: Identification and Validation of Proteinase 3 and Latent Matrix-Metalloproteinase 9 as Potential Biomarkers for Chronic Lung Transplant Rejection

Fig. 4

ROC curve analysis of HNP, PR-3, IgM, and proMMP-9 normalized to various standards. The ROC curve analysis was performed for biomarker concentrations normalized to volume of BALF assayed (analysis marked 1), total protein (analysis marked 2), and lysozyme content (analysis marked 3) of BALF. a Human neutrophil defensins (HNP). Data were from a previous study 17. b Proteinase 3 (PR-3). c IgM. d Latent form of matrix metalloproteinase-9 (proMMP-9). Area under the curve (AUC) is given. An area of 1.0 represents perfect sensitivity and specificity, whereas an area of 0.5 represents random assignment

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