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Fig. 10 | Clinical Proteomics

Fig. 10

From: A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers

Fig. 10

Survival curves for subgroups identified by a functional proteomic classification of breast cancer. a Distant metastasis-free and b overall survival curves for six subgroups (Fig. 9a) identified by unsupervised hierarchical clustering of 128 breast tumors (Set A) with data derived from reverse phase protein array (RPPA) using 82 antibodies. The same color scheme is used to illustrate the six breast cancer subgroups in Figs. 9a and 10a and b. c Distant metastasis-free and d overall survival curves for two subgroups identified by hierarchical clustering analysis of 69 luminal breast tumors using 12 markers (Fig. 9c). The same color scheme is used to illustrate the two breast cancer subgroups in Fig. 9c and 10c and d. Subgroup i represents “luminal a” breast tumors as defined using functional proteomics and subgroup ii represents “luminal b” breast tumors as defined using functional proteomics

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