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Table 6 Reproducibility associated with biologic replicates in reverse phase protein arrays (RPPA)

From: A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers

Antibody

Correlation coefficient

AcCoAp

0.642918568

Akt

0.618759766

Aktp308

0.254004137

Aktp473

0.410063812

AMPK

0.513727089

AMPKp

0.536678994

B catenin

0.730700092

BADp

0.369340325

CCNB1

0.870882305

CCND1

0.625891268

Cleaved caspase 7

0.633270435

E cadherin

0.6183121

EGFR

0.68801607

EGFRp1068

0.405450715

ER

0.841639703

ERK2

0.736704897

ERp118

0.430508819

FKHRL1p318

0.691993326

GSK3

0.678269861

GSK3p21_9

0.592290954

HER2

0.217455474

HER2p1248

0.403034203

IGFR1

0.595481674

IGFR1p

0.436972091

JNK

0.424603378

JNKp183_5

0.543731864

MAPKp

0.79987626

MEK

0.579451091

MEK1-2p

0.659646302

mTOR

0.626602561

p110alpha

0.436998926

p27

0.849943011

p38

0.716704432

p38p180_2

0.608686332

p53

0.655654172

p70S6 Kinase

0.649534728

p70S6Kp389

0.115625786

PKCalphap657

0.58393973

pmTOR

0.006433235

PR

0.758475654

PTEN

0.529437664

Rab25

0.769013148

S6p235–236

0.720622398

S6p240_4

0.866983533

Src

0.71789969

srcp416

0.210019805

srcp527

0.625513318

stat3p705

0.539502613

stat3p727

0.550006586

stat6p

0.287410482

TSC2

0.647454784

TSC2p

0.538756346

  1. Correlation coefficients for the expression of 52 proteins and phosphoproteins across two independent sections obtained from each of 49 frozen human hormone receptor-positive breast cancers are shown. Cutoff for significance—0.282 (p = 0.05), 0.46 (p = 0.001)
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Clinical Proteomics

ISSN: 1559-0275