From: Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phosphorylation
Protein description | Modified peptide sequence | AA vs SS: Fold Change (p-value) | SS vs SS+U0126: Fold change (p-value) | SS vs SS+ERK2: Fold change (p-value) | SS+U0126 vs SS+U0126+ERK2: Fold change (p-value) | AA vs AA+ERK2: fold change (p-value) |
---|---|---|---|---|---|---|
60S acidic ribosomal protein P2 | KEES*EES*DDDMGFGLFD | 4.8 (7.24E-20) | −2.1 (3.61E-08) | NS | NS | NS |
Adenylyl cyclase-associated protein 1 | SGPKPFSAPKPQTS*PSPK | NS | −4.8 (2.00E-03) | NS | 5.3 (2.00E-04) | NS |
Alpha-adducin | QKGS*EENLDEAR | 2.5 (2.43E-33) | −4.1 (2.80E-45) | NS | 2.4 (1.25E-11) | NS |
Beta-adducin | ETAPEEPGS*PAKS*APAS*PVQSPAK | 5.6 (3.72E-28) | −1.9 (3.87E-09)* | NS | NS | 2.4 (4.21E-06)* |
Beta-adducin | ETAPEEPGSPAKS*APAS*PVQSPAK | NS | −1.8 (1.80E-02)* | NS | 1.8 (3.00E-02) | 1.8 (2.00E-02)* |
Beta-adducin | TESVTSGPMSPEGSPSKS*PSK | NS | −1.9 (3.00E-02) | NS | 1.9 (3.00E-03) | NS |
Dematin | QPLTSPGSVS*PSR | 7.9 (8.63E-05) | −4.4 (1.00E-03) | NS | NS | NS |
E3 ubiquitin-protein ligase UBR4 | T*SPADHGGSVGSESGGSAVDSVAGEHSVSGR | 3.6 (1.55E-18) | −1.8 (1.02E-07) | NS | NS | NS |
Eukaryotic translation initiation factor 4B | SQS*SDTEQQSPTSGGGK | 5.6 (9.74E-06) | −2.5 (4.00E-03) | NS | 2.0 (2.00E-02) | NS |
facilitated glucose transporter member 1 | QGGAS*QSDKTPEELFHPLGADSQV | 5.0 (7.45E-10) | −3.4 (7.99E-08) | NS | NS | NS |
Glycophorin-A | KS*PSDVKPLPSPDTDVPLSSVEIENPETS*DQ | 7.7 (9.74E-07) | −1.9 (2.10E-02) | NS | NS | 2.0 (5.00E-03) |
Glycophorin-A | KSPSDVKPLPS*PDT*DVPLS*SVEIENPETSDQ | 10.2 (1.05E-06) | −2.3 (5.00E-03) | NS | NS | 2.1 (8.04E-04) |
Glycophorin-A | S*PS*DVKPLPSPDTDVPLSSVEIENPETS*DQ | 6.3 (9.08E-07) | −2.0 (1.60E-02) | NS | NS | 1.9 (3.10E-02) |
Glycophorin-A | S*PS*DVKPLPSPDTDVPLSSVEIENPETSDQ | 6.3 (9.08E-07) | −2.0 (8.00E-03) | NS | NS | NS |
Glycophorin-A | SPSDVKPLPS*PDT*DVPLS*SVEIENPETSDQ | 7.4 (8.28E-06) | −1.9 (2.90E-02) | NS | NS | 1.9 (6.00E-03) |
Glycophorin-A | SPSDVKPLPS*PDT*DVPLSSVEIENPETSDQ | 5.0 (0.00E+00) | −2.0 (2.13E-07) | NS | NS | NS |
Glycophorin-A | SPSDVKPLPSPDT*DVPLS*SVEIENPETSDQ | 5.0 (0.00E+00) | −1.8 (4.80E-02) | NS | NS | NS |
Glycophorin-A | SPSDVKPLPSPDT*DVPLSSVEIENPETSDQ | 5.0 (0.00E+00) | −2.0 (2.59E-21) | NS | NS | NS |
Glycophorin-A | SPSDVKPLPSPDTDVPLS*S*VEIENPETSDQ | 5.1 (3.49E-06) | −2.2 (3.00E-03) | NS | NS | 2.7 (7.97E-05) |
Glycophorin-A | SPSDVKPLPSPDTDVPLSS*VEIENPETSDQ | NS | −1.9 (3.30E-07) | NS | NS | NS |
Glycophorin-A | SPSDVKPLPSPDTDVPLSSVEIENPET*SDQ | NS | −1.9 (1.82E-13) | NS | NS | NS |
Glycophorin-A | SPSDVKPLPSPDTDVPLSSVEIENPETS*DQ | NS | −1.8 (4.00E-03) | NS | NS | NS |
Leucine-rich repeats and immunoglobulin-like domains protein 2 | T*HPETIIALRGMNVTLTCTAVSSSDSPMST*VWR | NS | −2.9 (1.27E-23) | NS | 1.8 (2.65E-05) | NS |
Leucine-zipper-like transcriptional regulator 1 | MAGPGST*GGQIGAAALAGGAR | 88.6 (1.70E-02) | −6.5 (4.50E-02) | NS | 6.7 (4.54E-06) | NS |
Lipin-2 | S*GGDETPSQSSDISHVLETETIFTPSSVK | 3.0 (1.56E-08) | −1.9 (3.37E-04) | NS | NS | NS |
Metabotropic glutamate receptor 7 | LSHKPSDRPNGEAKT*ELCENVDPNS*PAAK | 2.4 (1.61E-15) | −1.9 (2.95E-09) | NS | NS | 2.3 (7.98E-15) |
Proteasome subunit alpha type-3 | ESLKEEDES*DDDNM | 2.8 (4.14E-11) | −1.8 (5.42E-06) | NS | NS | NS |
Protein MICAL-2 | VS*S*GIGAAAEVLVNLY*MNDHRPKAQAT*SPDLESMRK | NS | −4.1 (8.44E-05) | NS | NS | NS |
Protein Wnt-16 | HERWNCMITAAATTAPMGASPLFGYELS*SGTK | −2.2 (5.13E-05) | −2.0 (1.90E-02) | NS | NS | NS |
Spectrin beta chain, erythrocyte | LS*SS*WESLQPEPSHPY | 3.5 (4.17E-13) | −1.8 (5.56E-05) | NS | NS | 2.0 (9.30E-11) |
Spectrin beta chain, erythrocyte | QIAERPAEETGPQEEEGETAGEAPVS*HHAATER | 2.1 (6.00E-03) | −2.4 (5.77E-04) | NS | NS | NS |
Transmembrane protein 151B | SPPGS*AAGES*AAGGGGGGGGPGVSEELTAAAAAAAADEGPAR | NS | −2.9 (3.91E-05) | NS | NS | NS |
U3 small nucleolar RNA-associated protein 15 | VVHS*FDYAAS*ILSLALAHEDETIVVGMTNGILS*VKHR | NS | −2.9 (7.39E-11) | NS | 2.2 (6.08E-05) | 2.1 (9.39E-14) |
Uncharacterized protein LOC388588 | DGVS*LGAVS*STEEASR | NS | −1.8 (9.99E-05) | NS | NS | 2.2 (2.40E-09) |
Uncharacterized protein LOC388588 | DGVS*LGAVSST*EEASR | 2.2 (2.00E-02) | −1.8 (4.90E-02) | NS | NS | NS |
UV excision repair protein RAD23 homolog A | EDKS*PSEESAPTTSPESVSGSVPSSGSSGR | 5.0 (6.40E-38) | −2.0 (1.96E-14) | NS | NS | 2.2 (4.13E-32) |