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Table 1 Serine hydrolases detected in normal urine (n=62)

From: Proteomic characterization of serine hydrolase activity and composition in normal urine

Serine hydrolase

Uniprot number

Log(e)§

Acylamino-acid-releasing enzyme

P13798

-109.3

Alpha/beta hydrolase domain-containing protein 14B

Q96IU4

-81

Apolipoprotein(a)

P08519

-164.5

Azurocidin

P20160

-5

Bile salt-activated lipase*

P19835

-352.6

Cholinesterase

P06276

-10.7

Chymotrypsin-like protease CTRL-1

P40313

-7.4

Coagulation factor VII

P08709

-26.3

Coagulation factor IX

P00740

-33.4

Coagulation factor XI

P03951

-80.5

Coagulation factor XII

P00748

-103.4

Complement C1r subcomponent-like protein*

Q9NZP8

-371.6

Complement C1s subcomponent

P09871

-50

Complement factor D

P00746

-4.8

Complement factor I light chain

E7ETH0

-354.5

Dipeptidyl peptidase 2

Q9UHL4

-214.1

Dipeptidyl peptidase 4

P27487

-307.9

Furin

P09958

-113.6

Gamma-glutamyltranspeptidase 1

P19440

-190

Gamma-glutamyltransferase 6

Q6P531

-72

Group XV phospholipase A2

Q8NCC3

-98.4

Haptoglobin

P00738

-373.7

Hepatocyte growth factor activator

Q04756

-138.6

Kallikrein-1 (tissue kallikrein)*

P06870

-476.4

Kallikrein-2

P20151

-27

Kallikrein-11

Q9UBX7

-38.9

Lactotransferrin

P02788

-120.4

Lipoprotein lipase

P06858

-42.9

Lysosomal protective protein (Cathepsin A)*

P10619

-163.9

Lysosomal Pro-X carboxypeptidase

P42785

-186.9

Macrophage stimulating 1

G3XAK1

-82.3

Mannan-binding lectin serine protease 1

P48740

-40.7

Mannan-binding lectin serine protease 2*

O00187

-456.2

Membrane-bound transcription factor site-1 protease

Q14703

-61.2

Myeloblastin (Proteinase 3)*

P24158

-5.9

Neuropathy target esterase

Q8IY17

-13.5

Palmitoyl-protein thioesterase 1

P50897

-53.3

Palmitoyl-protein thioesterase 2

G8JLE1

-81.3

Phosphatidylcholine-sterol acyltransferase

P04180

-174

Plasminogen*

P00747

-556

Platelet-activating factor acetylhydrolase IB subunit alpha

I3L495

-4.5

Platelet-activating factor acethylhydrolase IB subunit beta

P68402

-12

Probable serine carboxypeptidase CPVL

Q9H3G5

-114.8

Prostasin (channel-activating protease 1)

Q16651

-258.5

Prostate specific antigen (Kallikrein-3)*

P07288

-603.5

Prothrombin*

P00734

-841.7

Retinoid-inducible serine carboxypeptidase

Q9HB40

-126.8

Serine protease 23

O95084

-24.3

Serine protease hepsin

P05981

-42.4

Serine protease HTRA1

Q92743

-42.8

Serine protease HTRA3

P83110

-7.1

S-formylgluthathione hydrolase*

P10768

-63.4

Sialate O-acetylesterase*

Q9HAT2

-301.1

Tissue-type plasminogen activator

P00750

-16.9

Transmembrane protease serine 2

O15393

-127.2

Transmembrane protease serine 13

E9PIJ5

-23.2

Tripeptidyl-peptidase 1

O14773

-416.7

Trypsin-1

P07477

-22.5

Tryptase alpha/beta-1

Q15661

-15.8

Urokinase-type plasminogen activator*

P00749

-311

Vitamin K-dependent protein C

P04070

-56.9

Vitamin K-dependent protein Z

P22891

-400.5

  1. §Log(e) The base-10 log of the expectation that any particular protein assignment was made at random (E-value).
  2. *Serine hydrolase that was identified in an active conformational state with ABPP, affinity purification and MS/MS.
  3. () Alternative nomenclature.