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Figure 5 | Clinical Proteomics

Figure 5

From: Epithelium percentage estimation facilitates epithelial quantitative protein measurement in tissue specimens

Figure 5

Immunoassay measurements of epithelial cell adhesion molecule (EpCAM) and cathepsin L (CTSL) protein expression after normalization by epithelium percentage. (A) Epithelium percentage estimated for 8 normal and 36 cancer tissue slides with computer-aided classification and pathologist estimation. (B) Scatter plot of computer-aided epithelium percentage estimated vs. pathologist estimation. (C) EpCAM ELISA measurements were adjusted with epithelium percentage estimated with the computer-aided method. (D) CTSL ELISA measurements were adjusted with epithelium percentage estimated with the computer aided method. (E) EpCAM ELISA measurements were adjusted with epithelium percentage estimated by a pathologist. (F) CTSL ELISA measurements were adjusted with epithelium percentage estimated by a pathologist. Corr: Pearson’s correlation coefficient. **, p < 0.01, compared to normal prostate tissue. ***, p < 0.001, compared to normal prostate tissue.

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