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Figure 1 | Clinical Proteomics

Figure 1

From: Chitotriosidase - a putative biomarker for sporadic amyotrophic lateral sclerosis

Figure 1

Mass spectrometric analysis of ALS-CSF samples: Toxicity assays (A & B) were performed. Histogram of MTT assay showing 40% reduction in the viability of NSC-34 cells upon exposure to 10%(v/v) ALS-CSF compared to the cells exposed to normal-CSF (###p < 0.001 vs. N-CSF) and 30% compared to normal controls (***p < 0.001 vs. NC; A). ALS-CSF caused significant increase in LDH activity when compared to control groups (***p < 0.001 vs. NC and $$$p < 0.001 vs. N-CSF; B). Gel image representing depletion of abundant proteins prior to mass spectrometric analysis (C). Representative MS/MS spectra of the peptides of CHIT1, Osteopontin, CHI3L1 and CHI3L2 (D). Tests of significance was Student’s t test, One way Anova followed by Tukey’s post hoc analysis.

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