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Table 2 Proteins that show increased expression in T21 amniocytes (n = 31)

From: Quantitative proteomic analysis of amniocytes reveals potentially dysregulated molecular networks in Down syndrome

Gene name

Protein name

Ratio (H/L)1

AK6

Adenylate kinase isoenzyme 6

2.70

AMIGO2

Amphoterin-induced protein 2

8.92

ARSA

Arylsulfatase A

1.71

CD9

CD9 antigen

2.48

CNN3

Calponin-3

1.82

COL8A1

Collagen alpha-1(VIII) chain

1.93

CPA4

Carboxypeptidase A4

4.84

CRYAB

Alpha-crystallin B chain

2.70

CTSZ

Cathepsin Z

1.96

DDAH1

N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

2.50

DNPEP

Aspartyl aminopeptidase

6.19

DPP7

Dipeptidyl-peptidase 2

2.31

GREM1

Gremlin-1

2.78

LCRMP

Collapsin response mediator protein 4 long variant

4.38

LPCAT2

Lysophosphatidylcholine acyltransferase 2

2.51

MFI2

Melanotransferrin

2.91

MYH10

Myosin-10

2.47

NAAA

N-acylethanolamine-hydrolyzing acid amidase

2.83

NAGLU

Alpha-N-acetylglucosaminidase

1.73

P4HA1

Prolyl 4-hydroxylase subunit alpha-1

1.98

PFKL

6-phosphofructokinase, liver type

1.98

PLOD2

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

7.77

PPME1

Protein phosphatase methylesterase 1

1.82

PYGL

Glycogen phosphorylase, liver form

1.81

S100A10

Protein S100-A10

2.34

SFXN1

Sideroflexin-1

1.71

SIAE

Sialate O-acetylesterase

1.87

SLC25A4

ADP/ATP translocase 1

2.24

SOD1

Superoxide dismutase [Cu-Zn]

1.91

TPM2

Tropomyosin beta chain

2.70

UAP1

UDP-N-acetylhexosamine pyrophosphorylase

1.96

  1. 1. Heavy/light ratio with SILAC method, calculated as the average of three experimental pairs when available. Only proteins which showed increased ratio for different peptides, as well as consistency in the pattern of expression of experimental pairs were selected.