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Table 3 Comparison of T21/CN ratios between SILAC and SRM analysis from a total of 8 experimental pairs (3 pairs for SILAC and 5 pairs for SRM experiments)

From: Quantitative proteomic analysis of amniocytes reveals potentially dysregulated molecular networks in Down syndrome

Gene

T21/CN ratios according to gestational age (weeks)

Name

15.1

15.5

15.9

16.3

16.4

17.3

18.6

21.5

NES

0.79*

0.19

0.34*

0.31*

0.17

1.26

0.67*

N/A

SOD1

1.54*

1.98

1.85*

1.46*

1.74

1.75*

1.16

2.02

  1. T21, Trisomy 21; CN, chromosomally normal; N/A: Not available.
  2. Bolded: Ratios (T21/CN) from SRM analysis.
  3. Italicized: Ratios (T21/CN) from SILAC analysis.
  4. *Statistically significant ratios at p < 0.001, according to Student’s t-test when the six replicates where compared.
  5. Only the results of two proteins with highly significant fold-change in four out of five sample pairs (SRM) are displayed.