Table 1 A partial list of proteins differentially expressed in rabies

1.

Contactin 1

CNTN1

Over expressed in glioblastoma and localized to the surface of GFAP, normally expressed by neurons and oligodendrocytes.

2.0

1.0

1.7

2.

NADH dehydrogenase (ubiquinone) Fe-S protein 3

NDUFS3

NDUFS3 has upregulated in cerebral cortex while decreased in synaptosomal complex as shown by the quantitative proteomic study in animal models of schizophrenia

2.1

1.6

2.6

3.

Syntaxin 1A

STX1A

Gene expression studies have shown that high functioning autism patients has increased expression of STX1A compared to normal cases.

2.4

-

3.9

4.

NADH dehydrogenase (ubiquinone) 1

NDUFAB1

An acyl carrier protein, which is a part of complex I encoded by mitochondrial DNA. Clinical spectrum of deficiency of complex I include muscle weakness.

2.4

2

3.7

5.

Tumor protein D52

TPD52

Calcium/calmodulin-dependent protein kinase mediated phosphorylation of TPD2 showed in rat brain studies.

1.4

2.8

2.4

6.

Calcium/calmodulin-dependent protein kinase IIA

CAMK2A

It is a calcium dependent serine/threonine kinase. It is required for hippocampal long-term potentiation (LTP) and spatial learning. It is critical in opioid-induced hyperalgesia

1.6

2.1

4.3

7.

Mitochondrial carrier homolog 2

MTCH2

Conditional knock out of MTCH2 has shown decreased Fas-induced apoptosis, possibly by preventing tBID recruitment to mitochondria.

2.7

-

-

8.

Glutamate-ammonia ligase

GLUL

Microarray studies has shown that altered expression of GLUL in major depressive disorder.

4.85

2.66

5.48

9.

Aldehyde dehydrogenase 2 family (mitochondrial)

ALDH2

Proteomic profiling of human anterior cingulate cortex from patients with schizophrenia has shown differential expression of ALDH2.

1.9

2.2

2.3

10

Growth associated protein 43

GAP43

A marker for neuronal regeneration, shown decreased expression in hilus and inner molecular layer of hippocampal formation from patients with schizophrenia.

4.3

2.1

2.6

11

KPNA4

KPN4 plays an important role in the nuclear import of viruses such as HIV-1.

3.1

7.3

12

Karyopherin alpha 4

IPO5

West Nile Virus enters the nucleus by importin mediated pathway.

2.9

1.9

1.9

13

Importin 5

PSMA2

Transcriptomic and proteomic analysis has shown differential expression of PSMA2 in response to enterovirus 71 in rabdomyosarcoma cells.

3.1

2.6

2.5

14

Optic atrophy 1 isoform 2

OPA1

Shotgun mass spectrometry study on dorsolateral prefrontal cortex from patients with schizophrenia has shown differential expression of OPA1.

5.1

1.5

1.2

15

Guanine nucleotide binding protein, alpha activating activity polypeptide O

GNAO1

GNAO1 functions as a switch in G-protein coupling.

2.2

1.6

2.3