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Table 2 Proteins detected with iTRAQ that are differentially expressed comparing benign and malignant serous ovarian cyst samples

From: Potential tumor biomarkers identified in ovarian cyst fluid by quantitative proteomic analysis, iTRAQ

Gene symbol Accession Protein name p-value Fold change
Less expressed in malignant samples
ASTL Q6HA08 Astacin-like metalloendopeptidase < 0.001 8.48
ALB P02768 Albumin 0.001 2.63
C7 P10643 Complement component 7 0.002 1.85
AMY1A P04745 Amylase, alpha 1A 0.01 6.93
SPARCL1 Q14515 SPARC-like 1 (hevin) 0.01 2.82
PLTP P55058 Phospholipid transfer protein 0.02 1.80
ABI3BP Q7Z7G0 Target of Nesh-SH3 (TARSH) 0.02 1.80
CTSD P07339 Cathepsin D 0.02 2.95
CHAF1A Q13111 Chromatin assembly factor 1, subunit A 0.03 1.93
COL6A3 P12111 Collagen, type VI, alpha 3 0.03 2.22
CRISP3 P54108 Cysteine-rich secretory protein 3 0.04 2.59
KIAA0196 Q12768 Strumpellin (STRUM) 0.04 1.92
MSLN Q13421 Mesothelin 0.04 3.02
OVGP1 Q12889 oviductal glycoprotein 1 0.05 6.53
More expressed in malignant samples
APOA1 P02647 Apolipoprotein A-I 0.002 2.62
APOB P04114 Apolipoprotein B 0.004 2.43
HSPA5 /GRP78 P11021 heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) 0.005 3.34
APOA4 P06727 Apolipoprotein A-IV 0.02 3.31
IDHC O75874 Isocitrate dehydrogenase 1 (NADP+) 0.02 4.27
ALDOA P04075 Aldolase A, fructose-bisphosphate 0.02 2.70
TPI1 P60174 Triosephosphate isomerase 1 0.02 2.18
GAPDH P04406 Glyceraldehyde-3-phosphate dehydrogenase 0.03 2.76
C4BPA P04003 Complement component 4 binding protein, alpha 0.03 1.80
CLTC Q00610 Clathrin, heavy chain 0.03 2.69
APOC1 P02654 Apolipoprotein C-I 0.04 1.87
S100A8 P05109 S100 calcium binding protein A8 0.04 4.35
SYT13 Q7L8C5 Synaptotagmin XIII 0.04 1.97
YWHAZ P63104 Tyrosine 3-monooxygenase/tryptophan 5-mono-oxygenase activation protein, zeta polypeptide 0.04 3.79
APCS P02743 Amyloid P-component , serum 0.04 2.12
SAA4 P35542 Serum amyloid A-4, constitutive 0.04 1.95
PRDX2 P32119 Peroxiredoxin 2 0.04 4.03
S100A9 P06702 S100 calcium binding protein A9 0.05 3.43