Figure 4

Altered CSF-TTR isoform profile in AD. Data show CSF total transthyretin (TTR) (A) and the fraction of non-modified TTR (B) in patients with Alzheimer’s disease (AD), mild cognitive impairment (MCI), normal pressure hydrocephalus (NPH) or healthy controls (HC). Horizontal red bars indicate median values. (C) Receiver operating characteristics (ROC) curve. Alzheimer’s disease (AD) (n = 39) were compared HC and NPH controls (n = 22). Area under curve (AUC) was 0.88 with p-value <0.0001, optimal cut-off is 72.1% non-modified TTR. (D) Levels of % non-modified TTR in CSF from patients with AD and the combined control group of NPH and HC. Statistical significant differences (pairwise analysis by the Mann–Whitney U test) are indicated with horizontal brackets (***, p < 0.001; **, p < 0.01 level; *, p < 0.05).