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Figure 5 | Clinical Proteomics

Figure 5

From: Distinct transthyretin oxidation isoform profile in spinal fluid from patients with Alzheimer’s disease and mild cognitive impairment

Figure 5

Multivariate data analysis. A, Venn diagram illustrating the combination of AD-panel results and % TTR modified results. From 37 patients diagnosed with probable AD, 32 have abnormal AD panel outcome and/or abnormal values for non-modified TTR (nm-TTR). Together, this gives a sensitivity of 86% and a specificity of 82% of the AD diagnosis versus the NPH and HC groups; B. scores and loadings plot of the principal components analysis (PCA) using Aβ1-42 (Aβ), t-tau (tTau), and p-tau181 (pTau) and the % fraction of non-modified TTR (nm-TTR) as input data in the Latentix v 2.11 program. Loading vectors are illustrated by arrows and red dots. Plot data were imported into GraphPad Prism for the graphic presentation.

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