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Table 1 Types of mass analyzers

From: Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery

 Mass analyzer

 Sampling

 Separation

 Typical resolution

Mass accuracy

     Tandem mass spectrometry

Quadrupole

Continuous ion beam

Trajectory stability

2,000

100 ppm

Triple quadrupoles: CID (precursor ion scan, product ion scan, neutral loss)

Low energy collision

Ion trap

Continuous ion beam

Frequency

4,000

100 ppm

CID MSn, ETD, ECD

Low energy collision

TOF

Pulsed ion beam

Flight time

10 000

10 ppm for reflection TOF

TOF/TOF: CID

High energy collision

Q-TOF: CID

Low energy collision

Orbitrap

Pulsed ion beam

Frequency

100,000

<5 ppm

CID, HCD, ETD

Low energy collision

FT-ICR

Pulsed ion beam

Frequency

105-106

<5 ppm

SORI-CID, ECD, IRMPD, EDD

Low energy collision