Table 1 Summary of Ingenuity Pathway Analysis (IPA)-generated functional pathways and diseases associated with elevated proteins identified from PsA SF
From: Identification of psoriatic arthritis mediators in synovial fluid by quantitative mass spectrometry
IPA | Number of components identified | Proteins | P-Value |
|---|---|---|---|
Diseases and disorders | |||
Connective tissue disorders | 8 | ACTA1, DEFA1, IGHM, PLS2, MMP1, MMP3, MPO, S100A9 | 1.21E-07 |
Inflammatory disease | 8 | ACTA1, DEFA1, IGHM, PLS2, MMP1, MMP3, MPO, S100A9 | 1.21E-07 |
Skeletal and muscular disorders | 8 | ACTA1, DEFA1, IGHM, PLS2, MMP1, MMP3, MPO, S100A9 | 1.21E-07 |
Inflammatory response | 10 | CTSG, FGA, PLS2, S100A9, APCS, MPO, SAA1, DEFA1, ORM1, MMP1 | 2.86E-06 |
Immunological disease | 5 | ACTA1, DEFA1, PLS2, MPO, S100A9 | 1.04E-04 |
Molecular and cellular functions | |||
Cell-to-cell signaling and interaction | 11 | CTSG, FGA, PLS2, S100A9, MPO, ORM1, DEFA1, APCS, APOC1, SAA1, MMP1 | 2.86E-06 |
Cellular movement | 8 | CTSG, DEFA1, SAA1, PLS2, MMP1, MMP3, S100A9, PFN1 | 5.69E-05 |
Antigen presentation | 1 | PLS2 | 2.11E-03 |
Cell cycle | 1 | PFN1 | 2.11E-03 |
Cell morphology | 2 | PLS2, PFN1 | 2.11E-03 |
Physiological system development and function | |||
Hematological system development and function | 10 | CTSG, FGA, PLS2, S100A9, MPO, ORM1, DEFA1, SAA1, APCS, IGHM | 2.86E-06 |
Immune cell trafficking | 10 | CTSG, FGA, PLS2, S100A9, MPO, ORM1, DEFA1, SAA1, MMP1, APCS | 2.86E-06 |
Tissue development | 8 | CTSG, FGA, PLS2, S100A9, MPO, ORM1, SAA1, ACTA1 | 2.86E-06 |
Cell-mediated immune response | 3 | CTSG, DEFA1, PLS2 | 1.51E-03 |
Organismal survival | 2 | ACTB, PLS2 | 3.33E-03 |
Top canonical pathways | |||
LXR/RXR activation | 5 | APOB, APOC1, FGA, ORM1, SAA1 | 2.70E-06 |
Acute phase response signaling | 5 | APCS, C4BP, FGA, ORM1, SAA1 | 1.53E-05 |
Clathirin-mediated endocytosis signaling | 5 | ACTA1, ACTB, APOB, APOC1, ORM1 | 2.61E-05 |
Granulocyte adhesion and diapedesis | 4 | ACTA1, ACTB, MMP1, MMP3 | 3.53E-04 |
Production of nitric oxide and reactive oxygen species in macrophages | 4 | APOB, APOC1, MPO, ORM1 | 3.09E-04 |