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Table 1 Summary of Ingenuity Pathway Analysis (IPA)-generated functional pathways and diseases associated with elevated proteins identified from PsA SF

From: Identification of psoriatic arthritis mediators in synovial fluid by quantitative mass spectrometry

IPA Number of components identified Proteins P-Value
Diseases and disorders
Connective tissue disorders 8 ACTA1, DEFA1, IGHM, PLS2, MMP1, MMP3, MPO, S100A9 1.21E-07
Inflammatory disease 8 ACTA1, DEFA1, IGHM, PLS2, MMP1, MMP3, MPO, S100A9 1.21E-07
Skeletal and muscular disorders 8 ACTA1, DEFA1, IGHM, PLS2, MMP1, MMP3, MPO, S100A9 1.21E-07
Inflammatory response 10 CTSG, FGA, PLS2, S100A9, APCS, MPO, SAA1, DEFA1, ORM1, MMP1 2.86E-06
Immunological disease 5 ACTA1, DEFA1, PLS2, MPO, S100A9 1.04E-04
Molecular and cellular functions
Cell-to-cell signaling and interaction 11 CTSG, FGA, PLS2, S100A9, MPO, ORM1, DEFA1, APCS, APOC1, SAA1, MMP1 2.86E-06
Cellular movement 8 CTSG, DEFA1, SAA1, PLS2, MMP1, MMP3, S100A9, PFN1 5.69E-05
Antigen presentation 1 PLS2 2.11E-03
Cell cycle 1 PFN1 2.11E-03
Cell morphology 2 PLS2, PFN1 2.11E-03
Physiological system development and function
Hematological system development and function 10 CTSG, FGA, PLS2, S100A9, MPO, ORM1, DEFA1, SAA1, APCS, IGHM 2.86E-06
Immune cell trafficking 10 CTSG, FGA, PLS2, S100A9, MPO, ORM1, DEFA1, SAA1, MMP1, APCS 2.86E-06
Tissue development 8 CTSG, FGA, PLS2, S100A9, MPO, ORM1, SAA1, ACTA1 2.86E-06
Cell-mediated immune response 3 CTSG, DEFA1, PLS2 1.51E-03
Organismal survival 2 ACTB, PLS2 3.33E-03
Top canonical pathways
LXR/RXR activation 5 APOB, APOC1, FGA, ORM1, SAA1 2.70E-06
Acute phase response signaling 5 APCS, C4BP, FGA, ORM1, SAA1 1.53E-05
Clathirin-mediated endocytosis signaling 5 ACTA1, ACTB, APOB, APOC1, ORM1 2.61E-05
Granulocyte adhesion and diapedesis 4 ACTA1, ACTB, MMP1, MMP3 3.53E-04
Production of nitric oxide and reactive oxygen species in macrophages 4 APOB, APOC1, MPO, ORM1 3.09E-04