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Figure 5 | Clinical Proteomics

Figure 5

From: Critical comparison of sample preparation strategies for shotgun proteomic analysis of formalin-fixed, paraffin-embedded samples: insights from liver tissue

Figure 5

Impact of non-tryptic and formaldehyde-modified peptides. A) Left: Venn diagrams showing distribution of peptides identified with ‘trypsin’ and ‘no enzyme’ searches in DT (blue), FASP (red) and ISD (green) samples. Right: Venn diagram showing distribution of non-tryptic peptides among all methods. B) Left: Venn diagrams showing distribution of peptides identified with standard search (‘no mod’) and search comprising formaldehyde-induced modifications (‘mod’) in DT (blue), FASP (red) and ISD (green) samples. Right: Venn diagram showing distribution of formaldehyde-modified peptides among all methods.

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Clinical Proteomics

ISSN: 1559-0275