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Table 2 The classification of differentially expressed proteins in pre-B2 lymphoblastic cells from children with ALL

From: Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21)

Spots: statistic rank (2-DE batch)

Protein names [Homo sapiens]

NCBI and uniprot ID numbers

Fold changes/ALL t(12;21) versus others (average normalized volume +/- SD) 105

Group with the upper average volume

Student -t test

Power (after q value)

1 (2768)

CNN2

gi/49456619/ Q99439

1.9/(38.59 +/- 8.1 vs 20.76 +/- 4)

Pre - B2, t(12;21)

p ≤ 0.001

0.998

2 (3185)

CDSα

gi/32307132/ Q9Y697-1

2.2/(9.5 +/- 3.8 vs 20.98 +/- 5.2)

Other Pre - B2

p ≤ 0.001

0.985

3 (4083)

PITPβ

gi/6912594/ P48739

2/( 12.8 +/- 3.1 vs 6.28 +/- 2.21)

Pre - B2, t(12;21)

p ≤ 0.001

0.983

4 (2457)

hnRNP-E1

gi/460771/ Q15365

1.4/(29.87 +/- 4.69 vs 41.57 +/- 4.88)

Other Pre -B2

p ≤ 0.005

0.976

BUB3α

gi/4757880/ O43684

5 (4069)

PDH-E1

gi/149242791/ P13804 -1

1.5/(15.16 +/- 4.33 vs 23.29 +/- 3.12)

Other Pre -B2

p ≤ 0.005

0.955

6 (2090)

MAT2β i1

gi/11034825/ Q9NZL9

1.5/(21.94 +/- 3.89 vs 15.06 +/- 2.91)

Pre - B2, t(12;21)

p ≤ 0.005

0.915

7 (2800)

PSMB2

gi/4506195/ B7Z478

1.7/(9.48 +/- 2.49 vs 5.69 +/- 1.63)

Pre - B2, t(12;21)

p ≤ 0.01

0.878

8 (4081)

CECR5

gi/14861834/ Q9BXW7

1.3/(28.51 +/- 4.48 vs 37.3 +/- 4.81)

Other Pre - B2

p ≤ 0.01

0.867

BUB3α

gi/4757880/ O43684

9 (3121)

CK2α

gi/4503095/ P68400

1.5/(13.55 +/- 2.36 vs 20.31 +/- 4.9)

Other Pre - B2

p ≤ 0.01

0.864

SEPT9 i3

gi/668381/ Q9UHD8-3

10 (2056)

HnRNPA2

gi/4504447/ P22626-2

2/(18.28 +/- 6.56 vs 9.26 +/- 4.77)

Pre - B2, t(12;21)

p ≤ 0.01

0.854

11 (3120)

IVAD

gi/3212539/ P26440

1.5/( 14.98 +/- 3.44 vs 22.64 +/- 5.34)

Other Pre B2

p ≤ 0.01

0.835

FBA

gi/312137/ P05062

PSMB6

gi/1526426/ P62333

12 (2656)

OTUB1

gi/6841176/ Q96FW1

1.8/(58.54 +/- 19.8 vs (32.01 +/- 14.53)

Pre - B2, t(12;21)

p ≤ 0.05

0.787

  1. Two-dimensional gel electrophoresis (2-DE) Batches are located Figure 1A (in case of the top eleven) and Additional file 1: Figure S2 (for the following 15th). In column’ protein names, R1, R2 and R3 are the Mascot rank based on the whole ionic scores detected (upper or equal to 48). Power analysis is performed independently for each spot, taking into consideration the sample size and variance expression value (Progenesis SameSpots V4). CNN2 = calponin-2; CDSα = cysteine desulfurase, mitochondrial isoform a; PITPβ = phosphatidyl- inositol transfer protein beta isoform; BUB3a = mitotic checkpoint protein BUB3 isoform a; PDH E1 = chain A, pyruvate dehydrogenase E1 S264e Variant; MAT2β = methionine adenosyl transferase 2, subunit beta, isoform 1; PSMB2 = proteasome subunit beta type-2, isoform 1; CECR5 = cat eye syndrome critical region protein 5 isoform 2; CK2α = casein kinase II subunit alpha isoform a; SEPT9_i3 = MLL septin-like fusion protein MSF-B; hnRNPA2 = heterogeneous nuclear ribonucleo- proteins A2; IVAD = Chain A, isovaleryl-Coa dehydrogenase; FBA = fructose bisphosphate aldolase; PSMB6 = proteasome subunit 6 (p42); OTUB1 = deubiquitinating enzyme OTUB1.