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Table 2 The classification of differentially expressed proteins in pre-B2 lymphoblastic cells from children with ALL

From: Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21)

Spots: statistic rank (2-DE batch) Protein names [Homo sapiens] NCBI and uniprot ID numbers Fold changes/ALL t(12;21) versus others (average normalized volume +/- SD) 105 Group with the upper average volume Student -t test Power (after q value)
1 (2768) CNN2 gi/49456619/ Q99439 1.9/(38.59 +/- 8.1 vs 20.76 +/- 4) Pre - B2, t(12;21) p ≤ 0.001 0.998
2 (3185) CDSα gi/32307132/ Q9Y697-1 2.2/(9.5 +/- 3.8 vs 20.98 +/- 5.2) Other Pre - B2 p ≤ 0.001 0.985
3 (4083) PITPβ gi/6912594/ P48739 2/( 12.8 +/- 3.1 vs 6.28 +/- 2.21) Pre - B2, t(12;21) p ≤ 0.001 0.983
4 (2457) hnRNP-E1 gi/460771/ Q15365 1.4/(29.87 +/- 4.69 vs 41.57 +/- 4.88) Other Pre -B2 p ≤ 0.005 0.976
BUB3α gi/4757880/ O43684
5 (4069) PDH-E1 gi/149242791/ P13804 -1 1.5/(15.16 +/- 4.33 vs 23.29 +/- 3.12) Other Pre -B2 p ≤ 0.005 0.955
6 (2090) MAT2β i1 gi/11034825/ Q9NZL9 1.5/(21.94 +/- 3.89 vs 15.06 +/- 2.91) Pre - B2, t(12;21) p ≤ 0.005 0.915
7 (2800) PSMB2 gi/4506195/ B7Z478 1.7/(9.48 +/- 2.49 vs 5.69 +/- 1.63) Pre - B2, t(12;21) p ≤ 0.01 0.878
8 (4081) CECR5 gi/14861834/ Q9BXW7 1.3/(28.51 +/- 4.48 vs 37.3 +/- 4.81) Other Pre - B2 p ≤ 0.01 0.867
BUB3α gi/4757880/ O43684
9 (3121) CK2α gi/4503095/ P68400 1.5/(13.55 +/- 2.36 vs 20.31 +/- 4.9) Other Pre - B2 p ≤ 0.01 0.864
SEPT9 i3 gi/668381/ Q9UHD8-3
10 (2056) HnRNPA2 gi/4504447/ P22626-2 2/(18.28 +/- 6.56 vs 9.26 +/- 4.77) Pre - B2, t(12;21) p ≤ 0.01 0.854
11 (3120) IVAD gi/3212539/ P26440 1.5/( 14.98 +/- 3.44 vs 22.64 +/- 5.34) Other Pre B2 p ≤ 0.01 0.835
FBA gi/312137/ P05062
PSMB6 gi/1526426/ P62333
12 (2656) OTUB1 gi/6841176/ Q96FW1 1.8/(58.54 +/- 19.8 vs (32.01 +/- 14.53) Pre - B2, t(12;21) p ≤ 0.05 0.787
  1. Two-dimensional gel electrophoresis (2-DE) Batches are located Figure 1A (in case of the top eleven) and Additional file 1: Figure S2 (for the following 15th). In column’ protein names, R1, R2 and R3 are the Mascot rank based on the whole ionic scores detected (upper or equal to 48). Power analysis is performed independently for each spot, taking into consideration the sample size and variance expression value (Progenesis SameSpots V4). CNN2 = calponin-2; CDSα = cysteine desulfurase, mitochondrial isoform a; PITPβ = phosphatidyl- inositol transfer protein beta isoform; BUB3a = mitotic checkpoint protein BUB3 isoform a; PDH E1 = chain A, pyruvate dehydrogenase E1 S264e Variant; MAT2β = methionine adenosyl transferase 2, subunit beta, isoform 1; PSMB2 = proteasome subunit beta type-2, isoform 1; CECR5 = cat eye syndrome critical region protein 5 isoform 2; CK2α = casein kinase II subunit alpha isoform a; SEPT9_i3 = MLL septin-like fusion protein MSF-B; hnRNPA2 = heterogeneous nuclear ribonucleo- proteins A2; IVAD = Chain A, isovaleryl-Coa dehydrogenase; FBA = fructose bisphosphate aldolase; PSMB6 = proteasome subunit 6 (p42); OTUB1 = deubiquitinating enzyme OTUB1.