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Table 3 Concluding remarks and future directions

From: Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21)

Expression observed in t(12;21) ALLs Major expected cellular effects Comments Future directions
Over expression of CNN2 Mediates cellular growth arrest In favor of good prognosis associated to t(12;21) Is CNN2 a marker of good prognosis? It has to be confirmed with a largest group of patients
Over expression of MAT-2β Favors the cell proliferation with anti-apoptotic effect Would be a marker of cancer aggressiveness Would be explore as a target of chemotherapy
Over expression of hnRNPA2 Favors the cell proliferation Would be a marker of cancer aggressiveness Would be explore as a target of chemotherapy
Over expression of PITPβ Slow down the cell proliferation Is it a marker of good prognosis? Exploration of the balance PITPα/β
Under expression of BUB3 Avoid slippage of mitosis Over expression in non t(12;21) could lead to hypo/hyperpolyploid cells Mitoses analysis
Under expression of hnRNPE2 Favors apoptosis In favor of good prognosis associated to t(12;21) Exploration of the balance between hnRNPE2, PSMB2 and PSMB6 and/or checkup the apoptosis pathways
Over expression of PSMB2 Favors apoptosis
Under expression of PSMB6 Hinders apoptosis In favor of leukogenesis
Under expression of CK2α Slow down the proliferation by apoptotic effect In favor of good prognosis associated to t(12;21) Both expressions in combination with Ikaros (Ikzf1) phosphorylation and degradation ought to be clarified precisely
Over expression of HSPC263(OTUB1) Favors deubiquitination Does it prevent Ikaros (Ikzf1) degradation?
Under expression of metabolism pathway proteins (i.e., CDSα; CECR5; PDH; IVAD; IDH; Electron transfer flavoprotein) Sign the level of energetic consumption In favor of good prognosis associated to t(12;21) Checkup lymphoblasts metabolism pathway: High amount would be in accord with cancer aggressiveness