Table 2 Lung cancer classifier proteins ranked by gini importance score
From: Validation of a blood protein signature for non-small cell lung cancer
Protein [Entrez gene ID] | Name | Gini importance | Function | Up/down in NSCLC |
|---|---|---|---|---|
MMP12 [4321] | Matrix metallo-peptidase 12 | 20.33 | Breakdown of extracellular matrix, positive regulation of cell proliferation, tissue injury and remodeling | Up |
SERPINA3 [12] | Apha-1 antiproteinase | 14.11 | Serine protease inhibitor, part of acute phase response and tissue homeostasis | Up |
MMP7 [4316] | Matrix metallo-peptidase 7 | 13.73 | Breakdown of extracellular matrix, positive regulation of cell proliferation, collagen catabolism, degrades fibronectin | Up |
C9 [735] | Complement component 9 | 11.31 | Inflammatory acute phase reactant, pore-forming subunit of cytolytic MAC complex | Up |
CRP [1401] | C-reactive protein | 11.01 | Inflammatory acute phase reactant, immune effector | Up |
CNDP1 [84735] | Carnosine dipeptidase 1 | 8.66 | Carboxypeptidase, functions in amino acid transport and metabolism | Down |
CA6 [765] | Carbonic anhydrase VI | 7.62 | Reversible hydratation of carbon dioxide, one-carbon metabolism, nitrogen metabolism | Down |