The effect of disease on human cardiac protein expression profiles in paired samples from right and left ventricles

Table 3 Inter-disease trends: structural and cell signaling-related proteins

	Log₂fold diff. vs. RV_CAD
Protein [Swiss-Prot accession number]	LV_CAD	RV_AVS	LV_AVS
Structural
Actin, alpha skeletal muscle [P68133]	−0.15	0.75*^#	0.45
Versican core protein [P13611]	0.06	0.68*^#	1.04
Tubulin alpha-4A chain [P68366]	0.17	0.56*^#	0.41
Cofilin-2 [Q9Y281]	0.05	0.52*^#	0.38
Myopalladin [Q86TC9]	0.02	0.49*^#	0.42
Talin-2 [Q9Y4G6]	−0.02	−0.42*^#	−0.37
CLIP-associating protein 1 [Q7Z460]	0.11	0.29*	0.17
Ezrin [P15311]	−0.01	0.25*	0.16
Myosin-9 [P35579]	0.02	0.38	0.34*
LIM domain and actin-binding protein 1 [Q9UHB6]	0.14	0.22	0.46*
Myomesin-2 [P54296]	0.10	−0.05	−0.20^#
Myomesin-1 [P52179]	0.04	−0.10	−0.24^#
Cell Signaling
Inactive dual specificity phosphatase 27 [Q5VZP5]	0.02	0.67*^#	0.61
Protein phosphatase 1 regulatory subunit 7 [Q15435]	0.09	0.42*^#	0.21
Tight junction protein ZO-1 [Q07157]	0.08	0.40*^#	0.35
Heat shock protein beta-1 [P04792]	0.06	0.34*^#	0.26
Heat shock cognate 71 kDa protein [P11142]	0.06	0.22*^#	0.14
10 kDa heat shock protein, mitochondrial [P61604]	0.24*	0.41*	0.32
Glycogen synthase kinase-3 beta [P49841]	0.05	0.39*	0.32
Apoptosis-inducing factor 1, mitochondrial [O95831]	0.12	0.33*	0.22
Thioredoxin-dependent peroxide reductase, mitochondrial [P30048]	0.12	0.32*	0.22
Calsequestrin-2 [O14958]	0.03	0.31*	0.14
78 kDa glucose-regulated protein [P11021]	0.07	0.29*	0.22
Stress-70 protein, mitochondrial [P38646]	0.13	0.26*	0.21
Heat shock protein beta-7 [Q9UBY9]	−0.09	0.69^#	0.55
Glutathione S-transferase P [P09211]	0.09	−0.16	−0.19^#

Proteins (structural and cell signaling-related) significantly altered in one of the AVS ventricles compared to either the left or right ventricle of CAD group and had a similar trend in the adjacent AVS ventricle. Data are presented as log₂ fold difference compared to the right ventricle of the CAD patients.
*P < 0.05 vs. RV_CAD and ^#P < 0.05 vs. LV_CAD.
Fold diff. = Fold difference.

ISSN: 1559-0275