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Table 3 Inter-disease trends: structural and cell signaling-related proteins

From: The effect of disease on human cardiac protein expression profiles in paired samples from right and left ventricles

  Log2fold diff. vs. RVCAD
Protein [Swiss-Prot accession number] LVCAD RVAVS LVAVS
Structural
Actin, alpha skeletal muscle [P68133] −0.15 0.75*# 0.45
Versican core protein [P13611] 0.06 0.68*# 1.04
Tubulin alpha-4A chain [P68366] 0.17 0.56*# 0.41
Cofilin-2 [Q9Y281] 0.05 0.52*# 0.38
Myopalladin [Q86TC9] 0.02 0.49*# 0.42
Talin-2 [Q9Y4G6] −0.02 −0.42*# −0.37
CLIP-associating protein 1 [Q7Z460] 0.11 0.29* 0.17
Ezrin [P15311] −0.01 0.25* 0.16
Myosin-9 [P35579] 0.02 0.38 0.34*
LIM domain and actin-binding protein 1 [Q9UHB6] 0.14 0.22 0.46*
Myomesin-2 [P54296] 0.10 −0.05 −0.20#
Myomesin-1 [P52179] 0.04 −0.10 −0.24#
Cell Signaling
Inactive dual specificity phosphatase 27 [Q5VZP5] 0.02 0.67*# 0.61
Protein phosphatase 1 regulatory subunit 7 [Q15435] 0.09 0.42*# 0.21
Tight junction protein ZO-1 [Q07157] 0.08 0.40*# 0.35
Heat shock protein beta-1 [P04792] 0.06 0.34*# 0.26
Heat shock cognate 71 kDa protein [P11142] 0.06 0.22*# 0.14
10 kDa heat shock protein, mitochondrial [P61604] 0.24* 0.41* 0.32
Glycogen synthase kinase-3 beta [P49841] 0.05 0.39* 0.32
Apoptosis-inducing factor 1, mitochondrial [O95831] 0.12 0.33* 0.22
Thioredoxin-dependent peroxide reductase, mitochondrial [P30048] 0.12 0.32* 0.22
Calsequestrin-2 [O14958] 0.03 0.31* 0.14
78 kDa glucose-regulated protein [P11021] 0.07 0.29* 0.22
Stress-70 protein, mitochondrial [P38646] 0.13 0.26* 0.21
Heat shock protein beta-7 [Q9UBY9] −0.09 0.69# 0.55
Glutathione S-transferase P [P09211] 0.09 −0.16 −0.19#
  1. Proteins (structural and cell signaling-related) significantly altered in one of the AVS ventricles compared to either the left or right ventricle of CAD group and had a similar trend in the adjacent AVS ventricle. Data are presented as log2 fold difference compared to the right ventricle of the CAD patients.
  2. *P < 0.05 vs. RVCAD and #P < 0.05 vs. LVCAD.
  3. Fold diff. = Fold difference.