Proteomic analysis of human plasma in chronic rheumatic mitral stenosis reveals proteins involved in the complement and coagulation cascade

Table 1 Baseline Characteristics of Controls and Mitral Stenosis patients

Variables	Control (n = 19)	Rheumatic MS (n = 35)	p value
Age (years)	32.68 ± 1.77 (n = 19)	36.74 ± 1.43 (n = 35)	0.11
Male / Female	12 / 7	20 / 15	0.78
Clinical Presentation data
Pulse (bpm)	76 ± 1.82	78.37 ± 2.77 (n = 35)	0.96
SBP (mmHg)	119.79 ± 3.03	114.86 ± 2.60 (n = 35)	0.29
DBP (mmHg)	82.26 ± 1.42	75.60 ± 2.15 (n = 35)	0.03
Echocardiographic parameters (Normal range)
LA (20 – 40 mm)	30.88 ± 0.85 (n = 17)	48.58 ± 1.44 (n = 32)	<0.0001
LVIDd (35–56 mm)	43.53 ± 1.12 (n = 17)	44.77 ± 1.23 (n = 35)	0.52
LVIDs (24 - 42 mm)	29.24 ± 0.79 (n =17)	30.99 ± 0.93 (n = 35)	0.23
LVPW (6 -11 mm)	8.35 ± 0.26 (n = 17)	8.63 ± 0.26 (n = 32)	0.32
IVSD (6–11 mm)	8.53 ± 0.23 (n = 17)	9.11 ± 0.26 (n = 33)	0.12
EF (%)	66.82 ± 0.83 (n = 17)	56.80 ± 1.16 (n = 35)	<0.0001
PASP (mmHg)	-	57.32 ± 4.22 (n = 22)	NA
MVA (sq.mm)	-	87 ± 4 (n = 33)	NA
Fractional shortening (%)	32.73 ± 1.04 (n = 17)	30.71 ± 0.94 (n = 35)	0.19

bpm beats per minute, EF ejection fraction, IVSD interventricular septal diameter, LA left atrium, LVIDd left ventricular internal diameter diastolic, LVIDs left ventricular internal diameter systolic, LVPW left ventricular posterior wall, MVA mitral valve area, n number of subjects, NA not applicable, NYHA New York Heart Association, PASP pulmonary artery systolic pressure, SBP systolic blood pressure. Values indicate mean ± standard error of mean. p < 0.05 considered statistically significant between two groups.

ISSN: 1559-0275