Table 2 A partial list of downregulated regulated proteins in toxoplasma encephalitis

1

ASPA

Aspartoacylase

It catalyzes the hydrolysis of N-acetyl aspartate (NAA) to form aspartate and acetate. Accumulation of NAA due to deficiency of ASPA results in seizures and loss of previously acquired skills.

3.7

2

PLP1

Myelin proteolipid protein

It is a transmembrane proteolipid protein, which synthesizes and/or maintains multi lamellar structure of myelin.

3.4

3

RHOG

Rho-related GTP-binding protein, member G

It belongs to RHO family of small GTPase superfamily. It has a role in cytoskeleton arrangement and various Rho and Rac mediated signal transduction.

2.7

4

CBR1

Carbonyl reductase1

It is a monomeric enzyme, which metabolizes toxic environmental quinones and pharmacological substrates including anticancer doxorubicin.

2.6

5

GPD1

Glycerol-3-phosphate dehydrogenase

It has a major role in NADH oxidation, gluconeogenesis, triglyceride biosynthetic process and various other metabolic pathways.

2.4

6

VAT1

Synaptic vesicle membrane protein VAT-1

It belongs to quinone oxidoreductase subfamily under the family named zinc-containing alcohol dehydrogenase proteins. It inhibits mitochondrial fusion by acting along with mitofusin proteins.

2.3

7

RAP1A

Ras-related protein Rap-1A

It is a member of the Ras family of small GTPases, which is known to regulate cell-cell adhesion. Depletion of RAP1 is shown to increase endothelial permeability.

2.2

8

HSPA2

Heat shock-related 70 kDa protein 2

It belongs to heat shock protein 70 family. It has a role in synaptonemal complex disassembly.

2.2

9

PRKAR1A

cAMP-dependent protein kinase type I-alpha regulatory subunit

It belongs to cAMP-dependent kinase regulatory chain family having role in mesoderm formation, blood coagulation and various signal transduction pathways.

2.1

10

CRYL1

Lambda-crystallin homolog

It belongs to the family of oxidoreductase. It has a role in fatty acid metabolism.

1.7