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Table 2 Differential protein expressions in STBM isolated from patients with PE (n = 3) versus that from pregnant controls (n = 6)

From: Proteomic analysis of human placental syncytiotrophoblast microvesicles in preeclampsia

aProtein name

Symbol

Accession number

Molecular weight

bMean PE

cSEM PE

Mean NP

SEM NP

p-value

isoform 1 of Annex in A2

ANXA2

IPI004553 15

39 kDa

-

-

66.32

16.12

-

isoform 2 of Annex in A2

ANXA2

IPI00418169

40 kDa

94.32

13.51

-

-

-

annex in A4

ANXA4

IPI00793199

36 kDa

109.78

24.56

47.36

9.72

0.0227

Histone H 14

HST1HiE

IPI00217467

22 kDa

-

-

23.84

4.47

-

Histone 1.5

HST1H1B

IPI00217468

23 kDa

-

-

6.56

169

-

Isoform 1 of Intergrin alpha-V

ITGAV

IPI00027505

116 kDa

-

-

25.60

4.02

-

Isoform Beta-1A of Intergrin beta-1

ITGB 1

IPI00217563

88 kDa

4.24

4.24

19.15

3.43

0.0353

Glyceraldehyde-3-phospahte dehydrogenase

GAPDH

IPI00219018

36 kDa

51.76

22.95

9.48

3.18

0.0312

Heat schock protein beta-1

HSPB

IPI00025512

23 kDa

13.54

6.24

2.85

0.76

0.0398

Isoform 1 of Heat shock cognate 71 kDa protein

HSPA8

IPI00003865

71 kDa

10.31

3.99

1.97

0.67

0.0202

14-3-3 protein epsillon

YWHAE

IPI00000816

29 kDa

11.18

3.17

-

-

-

Actin, cytoplasmic 1

ACTB

IPI00021439

42 kDa

35.21

13.53

-

-

-

ADP-ribosylation factor 1

ARF 1

IPI00215914

21 kDa

6.72

2.60

-

-

-

Alpha-actinin-1

ACTN 1

IPI00013508

103 kDa

21.58

1.97

-

-

-

CD59 glycoprotein

CD59

IPI00011302

14 kDa

-

-

9.61

2.11

-

EF-hand domain-containing protein D1

EFHD1

IPI00031091

27 kDa

5.87

3.48

-

-

-

Ezrin

EZR

IPI00843975

69 kDa

40.30

15.01

1.17

0.98

0.0056

HSPA5 protein

HSPA 5

IPI00003362

72 k Da

10.80

3.96

-

-

-

Isoform 1 of Brain acid soluble protein 1

BASP1

IPI00299024

23 kDa

15.57

4.32

6.29

1.54

0.0373

Isoform alpha-enolase of Alpha-eno lase

EN01

IPI00465248

47 kDa

12.22

6.22

1.96

0.69

0.0446

Isoform M2 of Pyruvate Kinase Isozymes Mv M2

PKM

IPI00479186

58 kDa

7.45

4.15

-

-

-

Transketo lase

TKT

IPI00643920

69 kDa

9.67

4.49

1.33

0.95

0.0374

Tubullin alpha-1C cahin

TUBA 1C

IPI00218343

50 kDa

10.24

4.47

0.33

0.33

0.0125

Tubullin beta-2C cahin

TUBB4B

IPI00007752

50 kDa

5.98

3.10

-

-

-

dTubullin, beta

TUBB

IPI00645452

48 kDa

6.13

3.89

-

-

-

  1. aOnly proteins with a fold change >2 or <0.5 and p-value <0.05 or expressed only in one group (either PE or NP) are listed.
  2. bNumbers represent total spectral from all the peptides of a given protein.
  3. cResults are mean and standard error of mean (SEM), comparisons using t test between patients with preciamsia (PE n = 3) versus that from normal pregnant conrols (NP, n = 6).
  4. dFor complete list of all STBM proteins see Additional file4: Table S2 in Supplementary data.
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Clinical Proteomics

ISSN: 1559-0275