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Figure 4 | Clinical Proteomics

Figure 4

From: Proteomic signatures of serum albumin-bound proteins from stroke patients with and without endovascular closure of PFO are significantly different and suggest a novel mechanism for cholesterol efflux

Figure 4

HDL and Cholesterol levels measured by colorimetric assay in samples before and after stroke–related PFO closure. HDL and cholesterol were measured in a separate validation cohort (n = 104, Table 1). All patients had CLIO certified cholesterol and HDL measured pre and post PFO closure at the same time interval as the exploratory cohort. Conditional logistic regression analysis (Table 4) demonstrated that cholesterol levels were statistically decreased (p-value 0.0007) and HDL levels were statistically increased (p-value 0.0031) post PFO closure when compared to baseline levels.

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