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Table 3 Models for Recurrence-Free Survival and likelihood of pathological complete response

From: Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer

 

RFS

pCR

Univariate Models

      

Variable

Hazard Ratio

95% CI

Log-rank P-value

Odds Ratio

95% CI

Wald's P-Value

Prognostic Group 1

1.59

(.87, 2.90)

 

3.54

(.06, 28.14)

 

Prognostic Group 2

1.00

(1.0, 1.0)

 

1.00

  

Prognostic Group 3

1.15

(.51, 2.60)

 

2.16

(.32, 17.82)

 

Prognostic Group 4

3.12

(1.64, 5.90)

 

7.19

(1.77, 48.89)

 

Prognostic Group 5

3.01

(1.67, 5.41)

 

4.24

(.90, 30.76)

 

Prognostic Group 6

7.00

(3.53, 13.86)

<.0001

11.50

(1.40, 123.05)

.0519

Tumor size (</ = 2 cm vs. > 2 cm)

1.85

(1.16, 2.96)

.0094

1.30

(.56, 2.94)

.5364

Node status (positive vs. negative)

2.93

(1.99,4.29)

<.0001

1.11

(.50, 2.56)

.7981

Histologic grade (1 and 2 vs. 3)

3.70

(2.45, 5.60)

<.0001

4.35

(1.67, 13.62)

.0052

ER

0.82

(.76, .88)

<.0001

.73

(.56, .93)

.0180

PR

0.75

(.66, .85)

<.0001

.67

(.45, .91)

.0235

Bcl2

0.75

(.65, .86)

<.0001

.63

(.39, .96)

.0435

GATA3

0.77

(.66, .90)

.0010

.58

(.33, .95)

.0411

CCNB1

1.23

(1.12, 1.36)

<.0001

1.32

(1.00, 1.76)

.0449

CCNE1

1.40

(1.11, 1.76)

.0039

2.52

(1.32, 5.05)

.0062

EGFR

1.04

(.81,1.36)

.7437

1.54

(.90, 2.88)

.1333

HER2

1.21

(1.08, 1.36)

.0015

1.37

(.72, 2.57)

.3253

HER2p1248

1.18

(1.11, 1.26)

<.0001

1.09

(.74, 1.56)

.6528

EIG121

0.389

(.29, .52)

<.0001

.53

(.26, 1.05)

.0712

Prognostic score (continuous)

1.14

(1.10, 1.18)

<.0001

1.32

(1.12, 1.61)

.0021

Multivariate Models

      

Variable

Hazard Ratio

95% CI

Log-rank P-value

Odds Ratio

95% CI

Wald's P-Value

Clinical Characteristics Model

  

1.87E-12*

  

.021*

   Size

1.63

(.94, 2.85)

.0836

1.10

(.45, 2.63)

.8237

   Node

3.90

(2.25, 6.75)

<.0001

1.07

(.56, 2.58)

.8732

   Grade

2.75

(1.55, 4.85)

.0005

4.29

(1.64, 13.51)

.0057

Clinical Model + Prognostic Score

  

2.48E-12*

  

.004*

   Size

1.51

(.86, 2.65)

.1489

1.18

(.47, 2.88)

.7192

   Node

3.83

(2.22, 6.61)

<.0001

1.02

(.42, 2.51)

.9657

   Grade

2.23

(1.21, 4.13)

.0106

2.41

(.80, 8.27)

.1332

   Prognostic score

1.07

(.99, 1.16)

.0895

1.24

(1.03, 1.52)

.0327

Tumor Grade + Prognostic Score

     

.01*

   Grade

   

2.46

(.83, 8.40)

.1198

   Prognostic score

   

1.23

(1.03, 1.51)

.0283

  1. RFS: Recurrence-free survival; pCR; pathologic complete response. * X2 test
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Clinical Proteomics

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