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Figure 1 | Clinical Proteomics

Figure 1

From: Evaluating the potential of a novel oral lesion exudate collection method coupled with mass spectrometry-based proteomics for oral cancer biomarker discovery

Figure 1

"On-Strip" digestion method. In order to produce a peptide solution for MS-based proteomics analysis, we first dried oral epithelium to remove ambient saliva, then placed a PerioPaper strip on the location of interest (Oral Pre-Malignant lesion or normal oral epithelium) and allowed it to absorb exudate. The PerioPaper was next placed in trypsin solution for digestion of proteins to peptides for subsequent processing and mass spectrometry analysis. See Experimental Methods for details.

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