Table 1 Selected proteins showing increased relative abundance in OPML tissue compared to healthy
Protein | Quantitative ratio1 | P value1 | Evidence of association with OPML and/or epithelial inflammation |
|---|---|---|---|
hnRNPM | 8.00 | 0.091 | RNA binding, splicing and inflammation signaling; increased abundance of hnRNPs has been measured in OPML tissue 17 |
IL1F6 | 22.00 | 0.016 | Cytokine involved in inflammation and immune response; increases in abundance in inflamed epithelial tissues 24; 25 |
LCN2 | 4.00 | 0.021 | Iron transporter involved in immune response and apoptosis; activated in inflammatory and pre-malignant tissues 26; 27 |
S100A8 | 2.02 | 0.088 | Calcium binder and pro-inflammatory factor; increases in abundance in OPML tissue 18 |
NQO1 | 10.00 | 0.050 | Quinone reductase; induced under inflammatory conditions 28 |
XRCC5/6 | 4.00/8.00 | 0.016/0.001 | Protein complex involved in DNA repair; DNA damage response proteins known to be activated in OPML 19 and other dysplastic epithelial lesions 29 |