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Table 1 Proteins higher in abundance in tumour relative to matched normal mucosa

From: Desmin expression in colorectal cancer stroma correlates with advanced stage disease and marks angiogenic microvessels

  

2D DIGE DeCyderâ„¢ calculations

Mass spectrometry

Spot number

Protein identified

Patient

T-N spot volume ratio

Ave. Ratio

P value

Score

Peptides Matched

% seq. MS/MS

1

Desmin

1

2.79

2.25

0.02

500 b

11

31

 

P17661a

2

1.19

     
  

3

1.58

     
  

4

3.45

     

2

HSP60

1

3.51

2.57

0.01

12.4c

7

10

 

P10809

2

1.46

     
  

3

1.91

     
  

4

3.10

     

3

14-3-3 β

1

1.48

2.0

0.01

234 b

6

28

 

P31946

2

1.57

     
  

3

1.65

     
  

4

3.46

     

4

β Tubulin

1

1.59

2.98

0.017

117b

2

5

 

P07437

2

3.01

     
  

3

3.55

     
  

4

2.42

     
  1. a, UniProtKB database accession number; b, Probability-based Mowse score (Mascot search engine at Matrixscience.com); c, Protein Lynx score (Protein Lynx Global server) - an algorithm based measure of confidence of protein identity; d, Percentage sequence coverage for MS/MS identification.
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Clinical Proteomics

ISSN: 1559-0275