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Table 2 List of differentially expressed serum proteins in visceral leishmaniasis identified by Q-TOF-MS/MSf

From: Two-dimensional difference gel electrophoresis (DIGE) analysis of sera from visceral leishmaniasis patients

Spot noa. Protein name Accession no.b Average ratiodratio ('p' (p value) Appaerance in gels (n = 18) Mascot Scoree Peptide matches Coverage (%)
129 C1 inhibitor gi|73858570 +1.45 (0.026) 18 190 22 32
1051 Alpha-1- acid glycoprotein gi|112877 +3.73 (0.009) 18 166 13 48
954 Transthyretin gi|126030594 -1.83 (0.001) 18 449 13 95
958 Transthyretin gi|126030594 -2.23 (0.011) 18 503 12 84
1050 Transthyretin gi|219978 -1.84 (0.015) 18 188 5 46
1049 Transthyretin gi|443295 -2.22 (0.011) 18 262 5 38
816 Retinol binding protein gi|4558179 -1.99 (0.009) 18 47 6 27
673 Apolipoprotein A-I gi|113992 -2.24 (0.013) 18 114 8 27
746 Apolipoprotein A-I LPHUA1c -1.65 (0.015) 18 314 28 63
  1. a Spot no. assigned in DeCyder analysis and corresponded to the DIGE image in Figure 1
  2. bAccession no. from NCBInr database, c MSDB database
  3. d+ indicates up-regulation and - indicates down-regulation of the protein in visceral leishmaniasis serum with reference to controls.
  4. e Mascot scores greater than 40 were considered significant
  5. f Details of all the mascot search results are provided as additional files 2 and 3.