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Table 1 The co-distribution of a risk marker (High/Low risk) and adverse event (+/- Toxicity) in response to standard treatment in two hypothetical patient populations (A, B).

From: Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia

Population A Outcome Low risk High risk
RR/OR - Toxicity 969 20
9.9/10.8 +Toxicity 9 2
Precision 2/(20+2): 9.1% Sensitivity 2/(9+2): 18%
Population B Outcome Low risk High risk
RR/OR - Toxicity 535 446
9.9/10.2 +Toxicity 2 17
Precision 17/(446+17): 3.7% Sensitivity 17/(2+17): 89%
  1. Precision and sensitivity calculated as explained in the main text. RR: Relative Risk; OR: Odds Ratio