Table 1 Potential functions of human ADAMs*
From: The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?
ADAM | Function/potential function |
|---|---|
Proteolytically inactive | Â |
ADAM2 | Sperm-egg fusion |
ADAM7 | Sperm maturation |
ADAM11 | Integrin ligand, neural adhesion, tumour suppressor |
ADAM18 | Oocyte recognition |
ADAM22 | Adhesion |
ADAM23 | Tumour suppressor |
ADAM29 | Unknown |
Proteolytically active* | Â |
ADAM8 | Shedding of adhesion molecules, leukocyte receptors, neutrophil infiltration, osteoclast stimulation |
ADAM9 | α-secretase activity, cellular adhesion |
ADAM10 | α-secretase activity, shedding of TNF α, EGF, betacellulin, HER2, Notch, and collagen IV, cellular adhesion |
ADAM12 | Cellular adhesion, shedding of HB-EGF |
ADAM15 | Cellular adhesion |
ADAM17 | Release of several growth factor ligands, e.g., TNF-alpha and specific EGFR/HER ligands, cellular adhesion |
ADAM19 | Unknown |
ADAM28 | Shedding of IGFBP3 |
ADAM33 | Involved in pathogenesis of gastric cancer via IL-18 secretion |