Immunohistochemical labeling of FTL protein downregulation in TBM. Normal controls (A-C): Intense labeling of grey and white matter (A). In the grey matter (B), the neurons (arrow) and dendritic processes are intensely labeled (B) while in the white matter (C), neuropil and oligodendroglial cells are stained intensely. TBM (D-F): In the grey and white matter of the frontal cortex, showed very light labeling in contrast to control. In the subpial zones and deep grey matter beneath the exudate and the inflammatory cells in the subarachnoid space are stained (E) while the neuropil and neurons are less intense. Microglial cells in white matter and perivascular zones show labeling (F). [A, D: whole mountsx10, B, C: xObj.20, E: xObj.x5, F: xObj.20].